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Review
. 2022 Dec;20(4):739-751.
doi: 10.1111/vco.12827. Epub 2022 Jul 4.

Diagnosis and histopathologic prognostication of canine melanocytic neoplasms: A consensus of the Oncology-Pathology Working Group

Affiliations
Review

Diagnosis and histopathologic prognostication of canine melanocytic neoplasms: A consensus of the Oncology-Pathology Working Group

Rebecca C Smedley et al. Vet Comp Oncol. 2022 Dec.

Abstract

One of the primary objectives of the Oncology Pathology Working Group (OPWG) is for oncologists and pathologists to collaboratively generate consensus documents to standardize aspects of and provide guidelines for veterinary oncologic pathology. Consensus is established through review of relevant peer-reviewed literature relative to a subgroup's particular focus. In this article, the authors provide a critical review of the current literature for the diagnosis of, and histopathologic prognostication for, canine cutaneous and oral/lip melanocytic neoplasms, suggest guidelines for reporting, provide recommendations for clinical interpretation, and discuss future directions. This document represents the opinions of the working group and the authors and does not constitute a formal endorsement by the American College of Veterinary Pathologists, American College of Veterinary Internal Medicine or the Veterinary Cancer Society.

Keywords: cancer; dogs; melanoma; oncology; pathology; prognosis.

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Conflict of interest statement

Philip J. Bergman is a paid consultant and speaker for Boerhinger Ingelheim Animal Health and also receives a minority royalty stream payment for the Oncept melanoma vaccine.

References

    1. Smedley RC, Spangler WL, Esplin DG, et al. Prognostic markers for canine melanocytic neoplasms: a comparative review of the literature and goals for future investigation. Vet Pathol. 2011;48:54‐72. †. - PubMed
    1. Webster JD, Dennis MM, Dervisis N, et al. Recommended guidelines for the conduct and evaluation of prognostic studies in veterinary oncology. Vet Pathol. 2011;48(1):7‐18. ‡. - PubMed
    1. Bongiovanni L, D'Andrea A, Porcellato I, et al. Canine cutaneous melanocytic tumours: significance of β‐catenin and survivin immunohistochemical expression. Vet Dermatol. 2015;26(4):270 †. - PubMed
    1. Campagne C, Julé S, Alleaume C, et al. Canine melanoma diagnosis: RACK1 as a potential biological marker. Vet Pathol. 2013;50(6):1083‐1090. †. - PubMed
    1. Finotello R, Monné Rodriguez JM, Vilafranca M, et al. Immunohistochemical expression of MDR1‐Pgp 170 in canine cutaneous and oral melanomas: pattern of expression and association with tumour location and phenotype. Vet Comp Oncol. 2017;15(4):1393‐1402. †. - PubMed