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. 2022 Aug;122(8):1843-1856.
doi: 10.1007/s00421-022-04956-w. Epub 2022 May 6.

Cerebrovascular function and its association with systemic artery function and stiffness in older adults with and without mild cognitive impairment

Tom G Bailey #  1   2 , Timo Klein #  1   3   4 , Annelise L Meneses  1 , Kayla B Stefanidis  1 , Stefanie Ruediger  2   3 , Daniel J Green  5 , Tim Stuckenschneider  1   3 , Stefan Schneider #  1   3 , Christopher D Askew #  6   7
Affiliations

Cerebrovascular function and its association with systemic artery function and stiffness in older adults with and without mild cognitive impairment

Tom G Bailey et al. Eur J Appl Physiol. 2022 Aug.

Abstract

Purpose: Our aim was to compare cerebrovascular and systemic vascular function between older adults with and without mild cognitive impairment (MCI), and to determine which measures of vascular function best predict the presence of MCI.

Methods: In 41 adults with MCI and 33 adults without MCI (control) we compared middle cerebral artery velocity (MCAv) and cerebrovascular pulsatility index (PI) at rest, cerebrovascular reactivity to CO2, and responsiveness to changes in blood pressure (%∆MCAv/%∆MAP). Systemic vascular function was assessed by flow-mediated dilation (FMD) and stiffness by pulse wave velocity (PWV).

Results: Cerebrovascular PI was higher in MCI compared with control (mean ± SD: 1.17 ± 0.27 vs. 1.04 ± 0.21), and MCI exhibited a lower %∆MCAv/%∆MAP (1.26 ± 0.44 vs. 1.50 ± 0.55%). Absolute (p = 0.76) and relative cerebrovascular reactivity to CO2 (p = 0.34) was similar between MCI and control. When age was included as a covariate the significant difference in cerebral PI between groups was lost. PWV was higher (13.2 ± 2.2 vs. 11.3 ± 2.5 m s-1) and FMD% (4.41 ± 1.70 vs. 5.43 ± 2.15%) was lower in MCI compared with control. FMD% was positively associated with PI across the cohort. Logistic regression analysis indicated that FMD and PWV significantly discriminated between MCI and controls, independent of age, whereas the inclusion of cerebrovascular measures did not improve the predictive accuracy of the model.

Conclusion: These findings raise the possibility that early changes in systemic vascular stiffness and endothelial function may contribute to altered cerebrovascular haemodynamics and impaired cognitive function, and present potential targets for prevention and treatment strategies in people with MCI.

Keywords: Cerebral blood flow; Cognition; Dementia; Flow-mediated dilation; Pulsatility index; Pulse wave velocity.

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Conflict of interest statement

The authors have no other interests to declare.

References

    1. Aaslid R, Markwalder TM, Nornes H. Noninvasive transcranial Doppler ultrasound recording of flow velocity in basal cerebral arteries. J Neurosurg. 1982;57(6):769–774. doi: 10.3171/jns.1982.57.6.0769. - DOI - PubMed
    1. Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, Gamst A, Holtzman DM, Jagust WJ, Petersen RC, Snyder PJ, Carrillo MC, Thies B, Phelps CH. The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 2011;7(3):270–279. doi: 10.1016/j.jalz.2011.03.008. - DOI - PMC - PubMed
    1. Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, Gamst A, Holtzman DM, Jagust WJ, Petersen RC, Snyder PJ, Carrillo MC, Thies B, Phelps CH. The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimer's Dementia. 2011;7(3):270–279. doi: 10.1016/j.jalz.2011.03.008. - DOI - PMC - PubMed
    1. Alwatban MR, Liu Y, Perdomo SJ, Ward JL, Vidoni ED, Burns JM, Billinger SA. TCD cerebral hemodynamic changes during moderate-intensity exercise in older adults. J Neuroimaging. 2019 doi: 10.1111/jon.12675. - DOI - PMC - PubMed
    1. Anzola GP, Galluzzi S, Mazzucco S, Frisoni GB. Autonomic dysfunction in mild cognitive impairment: a transcranial Doppler study. Acta Neurol Scand. 2011;124(6):403–409. doi: 10.1111/j.1600-0404.2011.01495.x. - DOI - PubMed

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