The Impact of a Prenatal Education Program for Opioid-Dependent Mothers on Breastfeeding Rates of Infants at Risk for Neonatal Abstinence Syndrome

doi:10.1007/s12325-022-02146-w

. 2022 Jul;39(7):3104-3111.

doi: 10.1007/s12325-022-02146-w. Epub 2022 May 6.

The Impact of a Prenatal Education Program for Opioid-Dependent Mothers on Breastfeeding Rates of Infants at Risk for Neonatal Abstinence Syndrome

Brian Brocato¹, David Lewis², Fabien Eyal³, Susan Baker⁴, Casey Armistead⁴, Alan David Kaye⁵, Elyse M Cornett⁶, Richard M Whitehurst Jr³

Affiliations

¹ Department of Obstetrics and Gynecology, University of Alabama, Birmingham, Birmingham, AL, USA.
² Department of Obstetrics and Gynecology, Louisiana State University Health, Shreveport, Shreveport, LA, USA.
³ Division of Neonatology, University of South Alabama, Mobile, AL, USA.
⁴ Department of Obstetrics and Gynecology, University of South Alabama, Mobile, AL, USA.
⁵ Departments of Anesthesiology and Pharmacology, Toxicology and Neurosciences, Louisiana State University Health Sciences Center, Shreveport, Shreveport, LA, USA.
⁶ Department of Anesthesiology, LSU Health Shreveport, Shreveport, LA, USA. elyse.bradley@lsuhs.edu.

PMID: 35522394
DOI: 10.1007/s12325-022-02146-w

The Impact of a Prenatal Education Program for Opioid-Dependent Mothers on Breastfeeding Rates of Infants at Risk for Neonatal Abstinence Syndrome

Brian Brocato et al. Adv Ther. 2022 Jul.

. 2022 Jul;39(7):3104-3111.

doi: 10.1007/s12325-022-02146-w. Epub 2022 May 6.

Authors

Brian Brocato¹, David Lewis², Fabien Eyal³, Susan Baker⁴, Casey Armistead⁴, Alan David Kaye⁵, Elyse M Cornett⁶, Richard M Whitehurst Jr³

Affiliations

¹ Department of Obstetrics and Gynecology, University of Alabama, Birmingham, Birmingham, AL, USA.
² Department of Obstetrics and Gynecology, Louisiana State University Health, Shreveport, Shreveport, LA, USA.
³ Division of Neonatology, University of South Alabama, Mobile, AL, USA.
⁴ Department of Obstetrics and Gynecology, University of South Alabama, Mobile, AL, USA.
⁵ Departments of Anesthesiology and Pharmacology, Toxicology and Neurosciences, Louisiana State University Health Sciences Center, Shreveport, Shreveport, LA, USA.
⁶ Department of Anesthesiology, LSU Health Shreveport, Shreveport, LA, USA. elyse.bradley@lsuhs.edu.

PMID: 35522394
DOI: 10.1007/s12325-022-02146-w

Abstract

Introduction: This study aimed to determine the effect of a prenatal education program for opioid-dependent women on breastfeeding frequency, newborn hospital length of stay, and cost of care for neonates at risk of developing neonatal abstinence syndrome.

Methods: From January 1, 2015 to January 1, 2020, opioid-dependent obstetric patients were educated on non-pharmacological preventative measures for neonatal abstinence syndrome (NAS), with focused counseling on breastfeeding. Data were collected and compared to a control group of opioid-dependent pregnant women who received standard care before initiation of the education program.

Results: Sample size calculation revealed that to detect doubling of the breastfeeding rate from 25% to 50% with 80% power and α error of 0.05, 66 participants were required in each group.

Conclusion: There were 75 women with opioid use disorder who had prenatal NAS education (study group) and 108 women with opioid use disorder who underwent standard care before NAS education (control group). Prenatal NAS education participants significantly increased breastfeeding initiation rates compared to the control group. Newborn length of stay significantly decreased after initiation of prenatal NAS education compared to the 36 months before NAS education program.

Keywords: Breastfeeding; Neonatal abstinence syndrome; Newborn; Opioid-dependent; Prenatal.

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References

1. Patrick SW. A comprehensive approach to the opioid epidemic. Obstet Gynecol. 2017;130(1):7–9. https://doi.org/10.1097/AOG.0000000000002118 . - DOI - PubMed
1. Paulozzi LJ, Mack KA, Hockenberry JM, Division of Unintentional Injury Prevention, National Center for Injury Prevention and Control, CDC. Vital signs: variation among states in prescribing of opioid pain relievers and benzodiazepines—United States, 2012. MMWR Morb Mortal Wkly Rep. 2014;26(63):563–568. https://www.cdc.gov/mmwr/preview/mmwrhtml/mm6326a2.htm .
1. Desai RJ, Hernandez-Diaz S, Bateman BT, Huybrechts KF. Increase in prescription opioid use during pregnancy among medicaid-enrolled women. Obstet Gynecol. 2014;123(5):997–1002. https://doi.org/10.1097/AOG.0000000000000208 . - DOI - PubMed - PMC
1. Patrick SW, Davis MM, Lehman CU, Cooper WO. Increasing incidence and geographic distribution of neonatal abstinence syndrome: United States 2009–2012. J Perinatol. 2015;35(8):650–5. https://doi.org/10.1038/jp.2015.36 . - DOI - PubMed - PMC
1. Patrick SW, Schumacher RE, Benneyworth BD, Krans EE, McAllister JM, Davis MM. Neonatal abstinence syndrome and associated health care expenditures: United States, 2000–2009. JAMA. 2012;307(18):1934–40. https://doi.org/10.1001/jama.2012.3951 . - DOI - PubMed

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[1] Patrick SW. A comprehensive approach to the opioid epidemic. Obstet Gynecol. 2017;130(1):7–9. https://doi.org/10.1097/AOG.0000000000002118 . - DOI - PubMed

[2] Patrick SW. A comprehensive approach to the opioid epidemic. Obstet Gynecol. 2017;130(1):7–9. https://doi.org/10.1097/AOG.0000000000002118 . - DOI - PubMed

[3] Paulozzi LJ, Mack KA, Hockenberry JM, Division of Unintentional Injury Prevention, National Center for Injury Prevention and Control, CDC. Vital signs: variation among states in prescribing of opioid pain relievers and benzodiazepines—United States, 2012. MMWR Morb Mortal Wkly Rep. 2014;26(63):563–568. https://www.cdc.gov/mmwr/preview/mmwrhtml/mm6326a2.htm .

[4] Paulozzi LJ, Mack KA, Hockenberry JM, Division of Unintentional Injury Prevention, National Center for Injury Prevention and Control, CDC. Vital signs: variation among states in prescribing of opioid pain relievers and benzodiazepines—United States, 2012. MMWR Morb Mortal Wkly Rep. 2014;26(63):563–568. https://www.cdc.gov/mmwr/preview/mmwrhtml/mm6326a2.htm .

[5] Desai RJ, Hernandez-Diaz S, Bateman BT, Huybrechts KF. Increase in prescription opioid use during pregnancy among medicaid-enrolled women. Obstet Gynecol. 2014;123(5):997–1002. https://doi.org/10.1097/AOG.0000000000000208 . - DOI - PubMed - PMC

[6] Desai RJ, Hernandez-Diaz S, Bateman BT, Huybrechts KF. Increase in prescription opioid use during pregnancy among medicaid-enrolled women. Obstet Gynecol. 2014;123(5):997–1002. https://doi.org/10.1097/AOG.0000000000000208 . - DOI - PubMed - PMC

[7] Patrick SW, Davis MM, Lehman CU, Cooper WO. Increasing incidence and geographic distribution of neonatal abstinence syndrome: United States 2009–2012. J Perinatol. 2015;35(8):650–5. https://doi.org/10.1038/jp.2015.36 . - DOI - PubMed - PMC

[8] Patrick SW, Davis MM, Lehman CU, Cooper WO. Increasing incidence and geographic distribution of neonatal abstinence syndrome: United States 2009–2012. J Perinatol. 2015;35(8):650–5. https://doi.org/10.1038/jp.2015.36 . - DOI - PubMed - PMC

[9] Patrick SW, Schumacher RE, Benneyworth BD, Krans EE, McAllister JM, Davis MM. Neonatal abstinence syndrome and associated health care expenditures: United States, 2000–2009. JAMA. 2012;307(18):1934–40. https://doi.org/10.1001/jama.2012.3951 . - DOI - PubMed

[10] Patrick SW, Schumacher RE, Benneyworth BD, Krans EE, McAllister JM, Davis MM. Neonatal abstinence syndrome and associated health care expenditures: United States, 2000–2009. JAMA. 2012;307(18):1934–40. https://doi.org/10.1001/jama.2012.3951 . - DOI - PubMed

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The Impact of a Prenatal Education Program for Opioid-Dependent Mothers on Breastfeeding Rates of Infants at Risk for Neonatal Abstinence Syndrome

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The Impact of a Prenatal Education Program for Opioid-Dependent Mothers on Breastfeeding Rates of Infants at Risk for Neonatal Abstinence Syndrome

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