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. 2022 May 6;27(5):414-423.
doi: 10.1093/oncolo/oyac023.

Characteristics of Anaplastic Oligodendrogliomas Short-Term Survivors: A POLA Network Study

Louis Garnier  1 , Chrystelle Vidal  2 , Olivier Chinot  3 , Elisabeth Cohen-Jonathan Moyal  4 , Apolline Djelad  5 , Charlotte Bronnimann  6 , Lien Bekaert  7 , Luc Taillandier  8 , Jean-Sébastien Frenel  9 , Olivier Langlois  10 , Philippe Colin  11 , Philippe Menei  12 , Frédéric Dhermain  13 , Catherine Carpentier  14 , Aurélie Gerazime  2 , Elsa Curtit  15 , Dominique Figarella-Branger  16 , Caroline Dehais  14 , François Ducray  1   17
Affiliations

Characteristics of Anaplastic Oligodendrogliomas Short-Term Survivors: A POLA Network Study

Louis Garnier et al. Oncologist. .

Abstract

Background: Anaplastic oligodendrogliomas IDH-mutant and 1p/19q codeleted (AO) occasionally have a poor outcome. Herein we aimed at analyzing their characteristics.

Methods: We retrospectively analyzed the characteristics of 44 AO patients with a cancer-specific survival <5 years (short-term survivors, STS) and compared them with those of 146 AO patients with a survival ≥5 years (classical survivors, CS) included in the POLA network.

Results: Compared to CS, STS were older (P = .0001), less frequently presented with isolated seizures (P < .0001), more frequently presented with cognitive dysfunction (P < .0001), had larger tumors (P = .= .003), a higher proliferative index (P = .= .0003), and a higher number of chromosomal arm abnormalities (P = .= .02). Regarding treatment, STS less frequently underwent a surgical resection than CS (P = .= .0001) and were more frequently treated with chemotherapy alone (P = .= .009) or with radiotherapy plus temozolomide (P = .= .05). Characteristics independently associated with STS in multivariate analysis were cognitive dysfunction, a number of mitosis > 8, and the absence of tumor resection. Based on cognitive dysfunction, type of surgery, and number of mitosis, patients could be classified into groups of standard (18%) and high (62%) risk of <5 year survival.

Conclusion: The present study suggests that although STS poor outcome appears to largely result from a more advanced disease at diagnosis, surgical resection may be particularly important in this population.

Keywords: Karnofsky Performance Status; age; anaplastic oligodendroglioma; chemotherapy; proliferation; radiotherapy; seizure; surgery.

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Figures

Figure 1.
Figure 1.
Representative examples of magnetic resonance imaging (MRI) presentation in 3 STS patients. Top: post-gadolinium axial T1-weighted images in 3 different STS patients (A, B, C) Bottom: corresponding axial Fluid-attenuated inversion recovery (FLAIR) (D, E, F).
Figure 2.
Figure 2.
Diagram of patient classification based on the presence of cognitive dysfunction, extent of surgery, and number of mitoses.
See this image and copyright information in PMC

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