Using MS induced pluripotent stem cells to investigate MS aetiology

Abstract

Multiple sclerosis (MS) is a complex disease, and its pathophysiology impacts the function of immune and central nervous system cell types. Despite extensive investigation into the aetiology of MS, the underlying cause/s remain elusive and consequently, faithful in vitro or in vivo preclinical models of MS do not exist. Advances in human stem cell technologies have enabled the generation of induced pluripotent stem cells (iPSCs) from people with MS. This review summarises the discoveries made using iPSCs derived from people with MS and explores their current and potential application/s in MS research.

Keywords: Disease modelling; Induced pluripotent stem cells (iPSCs); Microglia; Multiple sclerosis (MS); Neurons; Oligodendrocytes.