Comment
doi: 10.1016/j.molcel.2022.04.018.
Coping with starvation: Cysteine keeps mTORC1 suppressed to ensure survival
Affiliations
- PMID: 35523127
- DOI: 10.1016/j.molcel.2022.04.018
Item in Clipboard
Comment
Coping with starvation: Cysteine keeps mTORC1 suppressed to ensure survival
Mol Cell.
.
Abstract
Jouandin et al. (2022) show that lysosomal-derived cysteine serves as a signal to promote the tricarboxylic acid (TCA) cycle and suppress TORC1 signaling for Drosophila to endure starvation periods.
Copyright © 2022 Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interests The authors declare no competing interests.
Comment on
-
Lysosomal cystine mobilization shapes the response of TORC1 and tissue growth to fasting.Science. 2022 Feb 18;375(6582):eabc4203. doi: 10.1126/science.abc4203. Epub 2022 Feb 18. Science. 2022. PMID: 35175796 Free PMC article.