Nuclear factor programming improves stem-cell-derived hepatocyte phenotype
- PMID: 35523133
- DOI: 10.1016/j.stem.2022.04.009
Nuclear factor programming improves stem-cell-derived hepatocyte phenotype
Abstract
In this issue of Cell Stem Cell, Ma et al. demonstrate that the activation of the nuclear receptor thyroid hormone receptor beta (NR1A2) improves the differentiation status of hepatocyte-like cells derived from human pluripotent stem cells.
Copyright © 2022 Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interests D.H. is a founder, director, and shareholder in Stimuliver ApS and Stemnovate Limited.
Comment on
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The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes.Cell Stem Cell. 2022 May 5;29(5):795-809.e11. doi: 10.1016/j.stem.2022.03.015. Epub 2022 Apr 21. Cell Stem Cell. 2022. PMID: 35452598 Free PMC article.
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