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. 2022:2489:435-448.
doi: 10.1007/978-1-0716-2273-5_22.

Microarray-Based Screening of Putative HSP90 Inhibitors Predicted and Isolated from Microorganisms

Anusha Kishore  1 , Artem Fetter  1 , Carsten Zeilinger  2
Affiliations

Microarray-Based Screening of Putative HSP90 Inhibitors Predicted and Isolated from Microorganisms

Anusha Kishore et al. Methods Mol Biol. 2022.

Abstract

Protein microarrays are useful tools for detecting the presence of a target where different prey and bait combinations exist. Here we describe the extended application for a functional target-oriented screening assay with full length Heat shock proteins (HSPs ) for the identification of novel compounds.

Keywords: ATP-Cy5; Anti HSP90 inhibitor; Heat shock proteins; Natural products; Protein microarray.

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