Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 May 6;21(1):143.
doi: 10.1186/s12936-022-04172-z.

Assessing the effect of seasonal malaria chemoprevention on malaria burden among children under 5 years in Burkina Faso

Fati Kirakoya-Samadoulougou  1 , Vincent De Brouwere  2 , Arnold Fottsoh Fokam  3 , Mady Ouédraogo  4 , Yazoumé Yé  5
Affiliations

Assessing the effect of seasonal malaria chemoprevention on malaria burden among children under 5 years in Burkina Faso

Fati Kirakoya-Samadoulougou et al. Malar J. .

Abstract

Background: In 2014, the Burkina Faso government launched the Seasonal Malaria Chemoprevention (SMC) programme. Expected benefit was a 75% reduction of all malaria episodes and a 75% drop of severe malaria episodes. This study assessed SMC efficiency on malaria morbidity in the country after 2 years of implementation.

Methods: Quasi-experimental design comparing changes in outcomes during the high transmission period (August-November) between SMC and non-SMC health districts before (2013-2014) and after intervention (two rounds in 2015 and 2016). Health indicators (number of uncomplicated malaria cases (UM) and severe malaria cases (SM)) from 19 health districts (8 in intervention and 11 in comparison group) were extracted from the District Health Information System (DHIS2)-based platform including health facilities data. Effect on incidence was assessed by fitting difference-in difference mixed-effects negative binomial regression model at a log scale.

Results: The two rounds of SMC were associated with a reduction of UM incidence (ratio of incidence rate ratio (IRR) 69% (95% CI 55-86%); p = 0.001) and SM incidence (ratio of IRR = 73% (55-95%), p = 0.018) among under five children.

Conclusion: The two rounds of SMC had a significant effect on the reduction of malaria cases in under five children. This additional evidence on the effectiveness of SMC, using routine data, support the need to sustain its implementation and consider expansion to eligible areas not yet covered.

Keywords: Burkina Faso; Evaluation; Impact; Malaria; Seasonal malaria chemoprevention.

PubMed Disclaimer

Conflict of interest statement

The authors do not have any conflict of interest.

Figures

Fig. 1
Fig. 1
Health district selection flowchart. HD health district, SMC seasonal malaria chemoprophylaxis
Fig. 2
Fig. 2
Map of the selected health districts SMC in green and no-SMC in pink
Fig. 3
Fig. 3
Monthly trends of uncomplicated malaria incidence in health districts before and after SMC implementation
Fig. 4
Fig. 4
Monthly trends of severe malaria incidence in health districts before and after SMC implementation
See this image and copyright information in PMC

References

    1. Haakenstad A, Harle AC, Tsakalos G, Micah AE, Tao T, Anjomshoa M, et al. Tracking spending on malaria by source in 106 countries, 2000–16: an economic modelling study. Lancet Infect Dis. 2019;19:703–716. doi: 10.1016/S1473-3099(19)30165-3. - DOI - PMC - PubMed
    1. Ministère de la Santé. Directives nationales pour la prise en charge du paludisme dans les formations sanitaires du Burkina Faso. Programme National de Lutte contre le Paludisme; 2014. https://www.severemalaria.org/sites/mmv-smo/files/content/attachments/20....
    1. WHO. Policy recommendation: seasonal malaria chemoprevention (SMC) for Plasmodium falciparum malaria control in highly seasonal transmission areas of the Sahel sub-region in Africa. Geneva: World Health Organization; 2012. https://apps.who.int/iris/handle/10665/337978.
    1. WHO. Policy recommendation on intermittent preventive treatment during infancy with sulphadoxine–pyrimethamine (SP-IPTi) for Plasmodium falciparum malaria control in Africa. Geneva: World Health Organization; 2010. https://apps.who.int/iris/handle/10665/337977.
    1. WHO. Report of the technical consultation on seasonal malaria chemoprevention (SMC)/Chimio-prévention saisonnière du paludisme (CSP). Geneva: World Health Organization; 2011. https://www.who.int/malaria/publications/atoz/smc_report_teg_meetingmay2....