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Randomized Controlled Trial
. 2022 Aug;46(8):1721-1729.
doi: 10.1007/s00264-022-05416-y. Epub 2022 May 7.

Is intravenous tranexamic acid effective in reduction of blood loss during pelvic and acetabular surgery?

Mohamed M F Sharaby  1 , Younes M El-Deeb  2   3
Affiliations
Randomized Controlled Trial

Is intravenous tranexamic acid effective in reduction of blood loss during pelvic and acetabular surgery?

Mohamed M F Sharaby et al. Int Orthop. 2022 Aug.

Abstract

Purpose: Pelvic and acetabular surgery is associated with one of the highest amounts of blood loss. Tranexamic acid is a good choice to reduce blood loss during this type of surgery. However, being antifibrinolytic drug, the chance to have coagulation complications including DVT is a risk that should be considered particularly in such major trauma patients with the body's response to trauma and with possible prolonged bed stay. The aim of this study is to evaluate the effectiveness of intravenous tranexamic acid injection during pelvic and acetabular surgery for reduction of blood loss during surgery and after surgery and to evaluate any possible complications for its use.

Methods: This prospective randomized clinical trial includes 97 patients divided between two groups; group 1 (G1) which received TXA, while the second group (G2) is the control group. The primary outcome measures were total blood loss (TBL), allogenic blood units transfused, and the blood lost intra-operatively (IBL). The TBL was calculated by the haemoglobin balance method while the intra-operative blood loss was measured by the gravimetric method. Any complications related to the drug were evaluated particularly DVT.

Results: The study showed significantly less TBL (G1 = 829.7 ± 219.2, G2 = 1036.9 ± 314.9) and blood transfusion (G1 = 52.4 ± 40 g, G2 = 89.4 ± 60.6 g) in G1 compared to the G2.

Conclusion: This study proved the possible reduction of TBL and the need of blood transfusion by the use of TXA in pelvic and acetabular injuries.

Keywords: Acetabular fractures; Blood loss; Blood transfusion; Intravenous; Pelvic; Tranexamic acid.

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References

    1. McCormack PL (2012) Tranexamic acid: a review of its use in the treatment of hyperfibrinolysis. Drugs 72:585–617. https://doi.org/10.2165/11209070-000000000-00000 - DOI - PubMed
    1. Blackmore CC, Jurkovich GJ, Linnau KF, Cummings P, Hoffer EK, Rivara FP (2003) Assessment of volume of hemorrhage and outcome from pelvic fracture. Archives of surgery (Chicago, Ill : 1960) 138:504–508; discussion 508–509. https://doi.org/10.1001/archsurg.138.5.504
    1. Magnussen RA, Tressler MA, Obremskey WT, Kregor PJ (2007) Predicting blood loss in isolated pelvic and acetabular high-energy trauma. J Orthop Trauma 21:603–607. https://doi.org/10.1097/BOT.0b013e3181599c27 - DOI - PubMed
    1. Yang Q, Wang T, Ai L, Jiang K, Tao X, Gong D, Chen N, Fu Y, Pan F (2020) Clinical outcomes of blood transfusion to patients with pelvic fracture in the initial 6 h from injury. Exp Ther Med 19:2252–2258. https://doi.org/10.3892/etm.2020.8445 - DOI - PubMed - PMC
    1. Eubanks JD (2010) Antifibrinolytics in major orthopaedic surgery. J Am Acad Orthop Surg 18:132–138 - DOI

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