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Review
. 2022 Oct;65(10):1959-1970.
doi: 10.1007/s11427-021-2090-3. Epub 2022 May 5.

Intra-articular injection of stromal vascular fraction for knee degenerative joint disease: a concise review of preclinical and clinical evidence

Yuan Liu #  1   2 , Liping Huang #  2 , Yi Zeng  1 , Mingyang Li  1 , Huiqi Xie  3 , Bin Shen  4
Affiliations
Review

Intra-articular injection of stromal vascular fraction for knee degenerative joint disease: a concise review of preclinical and clinical evidence

Yuan Liu et al. Sci China Life Sci. 2022 Oct.

Abstract

Autologous fat-derived stromal vascular fraction (SVF) is a mixed cell population that has been used for many years in regenerative plastic surgery. In terms of animal and clinical research, this concise review was performed to evaluate the efficacy of SVF in knee degenerative joint disease (KDJD), which could cause pain, disability and severely affect patients' lives. Thirteen studies retrieved and screened from the databases were included, including six animal studies and seven clinical trials. The meta-analysis of clinical research shows that intra-articular injection of SVF, in combination with adjuvant surgery, could alleviate pain and improve early functional recovery for patients with KDJD at Kellgren-Lawrence (KL) grades II-III.

Keywords: knee degenerative joint disease; meta-analysis; review; stromal vascular fraction.

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References

    1. Andia, I., Maffulli, N., and Burgos-Alonso, N. (2019). Stromal vascular fraction technologies and clinical applications. Expert Opin Biol Ther 19, 1289–1305. - PubMed - DOI
    1. Arden, N.K., Perry, T.A., Bannuru, R.R., Bruyère, O., Cooper, C., Haugen, I.K., Hochberg, M.C., McAlindon, T.E., Mobasheri, A., and Reginster, J.Y. (2021). Non-surgical management of knee osteoarthritis: comparison of ESCEO and OARSI 2019 guidelines. Nat Rev Rheumatol 17, 59–66. - PubMed - DOI
    1. Assiotis, A., To, K., Morgan-Jones, R., Pengas, I.P., and Khan, W. (2019). Patellar complications following total knee arthroplasty: a review of the current literature. Eur J Orthop Surg Traumatol 29, 1605–1615. - PubMed - DOI
    1. Bąkowski, P., Kaszyński, J., Baka, C., Kaczmarek, T., Ciemniewska-Gorzela, K., Bąkowska-Żywicka, K., and Piontek, T. (2021). Patients with stage II of the knee osteoarthritis most likely benefit from the intra-articular injections of autologous adipose tissue—from 2 years of follow-up studies. Arch Orthop Trauma Surg doi: https://doi.org/10.1007/s00402-021-03979-w .
    1. Banyard, D.A., Sarantopoulos, C.N., Borovikova, A.A., Qiu, X., Wirth, G. A., Paydar, K.Z., Haun, J.B., Evans, G.R.D., and Widgerow, A.D. (2016). Phenotypic analysis of stromal vascular fraction after mechanical shear reveals stress-induced progenitor populations. Plast Reconstr Surg 138, 237e–247e. - PubMed - PMC - DOI

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