Review

. 2022 May:81:100904.

doi: 10.1016/j.resmer.2022.100904. Epub 2022 May 4.

Cardiovascular manifestations secondary to COVID-19: A narrative review

C Fauvel¹, A Trimaille², O Weizman³, T Pezel⁴, D Mika⁵, V Waldmann⁶, A Cohen⁷, G Bonnet⁸

Affiliations

¹ Cardiology Department, Rouen University Hospital, Rouen 76000, France; Division of Cardiovascular Medicine, Wexner Medical Center, The Ohio State University, 410 West 10th Avenue, Columbus, OH 43210, USA. Electronic address: charles.fauvelccf@gmail.com.
² Department of Cardiovascular Medicine, Nouvel Hôpital Civil, Strasbourg University Hospital, Strasbourg 67000, France.
³ Cardiology Department, Institut Lorrain du Cœur et des Vaisseaux, CHU de Nancy, 54500, France.
⁴ Cardiology Department, Lariboisière Hospital, AP-HP, Université de Paris, Paris 75010, France.
⁵ Paris-Saclay University, Inserm, UMR-S 1180, Châtenay-Malabry 92296, France.
⁶ Cardiology Department, Hôpital Européen Georges Pompidou, Université de Paris, Paris 75015, France.
⁷ Department of Cardiology, Saint Antoine and Tenon Hospital, AP-HP, INSERM UMRS-ICAN 1166 and Sorbonne University, Paris, France.
⁸ Université de Bordeaux, 33000, France; Service Médico-Chirurgicale de Valvulopathies et Cardiomyopathies, Hôpital Cardiologique Haut-Lévêque, Centre Hospitalier Universitaire de Bordeaux, Pessac 33600, France.

PMID: 35525097
PMCID: PMC9065692
DOI: 10.1016/j.resmer.2022.100904

Review

Cardiovascular manifestations secondary to COVID-19: A narrative review

C Fauvel et al. Respir Med Res. 2022 May.

. 2022 May:81:100904.

doi: 10.1016/j.resmer.2022.100904. Epub 2022 May 4.

Authors

C Fauvel¹, A Trimaille², O Weizman³, T Pezel⁴, D Mika⁵, V Waldmann⁶, A Cohen⁷, G Bonnet⁸

Affiliations

¹ Cardiology Department, Rouen University Hospital, Rouen 76000, France; Division of Cardiovascular Medicine, Wexner Medical Center, The Ohio State University, 410 West 10th Avenue, Columbus, OH 43210, USA. Electronic address: charles.fauvelccf@gmail.com.
² Department of Cardiovascular Medicine, Nouvel Hôpital Civil, Strasbourg University Hospital, Strasbourg 67000, France.
³ Cardiology Department, Institut Lorrain du Cœur et des Vaisseaux, CHU de Nancy, 54500, France.
⁴ Cardiology Department, Lariboisière Hospital, AP-HP, Université de Paris, Paris 75010, France.
⁵ Paris-Saclay University, Inserm, UMR-S 1180, Châtenay-Malabry 92296, France.
⁶ Cardiology Department, Hôpital Européen Georges Pompidou, Université de Paris, Paris 75015, France.
⁷ Department of Cardiology, Saint Antoine and Tenon Hospital, AP-HP, INSERM UMRS-ICAN 1166 and Sorbonne University, Paris, France.
⁸ Université de Bordeaux, 33000, France; Service Médico-Chirurgicale de Valvulopathies et Cardiomyopathies, Hôpital Cardiologique Haut-Lévêque, Centre Hospitalier Universitaire de Bordeaux, Pessac 33600, France.

PMID: 35525097
PMCID: PMC9065692
DOI: 10.1016/j.resmer.2022.100904

Abstract

The coronavirus disease 2019 (COVID-19) pandemic has spread rapidly, becoming a major threat to global health. In addition to having required the adaptation of healthcare workers for almost 2 years, it has been much talked about, both in the media and among the scientific community. Beyond lung damage and respiratory symptoms, the involvement of the cardiovascular system largely explains COVID-19 morbimortality. In this review, we emphasize that cardiovascular involvement is common and is associated with a worse prognosis, and that earlier detection by physicians should lead to better management. First, direct cardiac involvement will be discussed, in the form of COVID-19 myocarditis, then secondary cardiac involvement, such as myocardial injury, myocardial infarction and arrhythmias, will be considered. Finally, worsening of previous cardiovascular disease as a result of COVID-19 will be examined, as well as long-term COVID-19 effects and cardiovascular complications of COVID-19 vaccines.

Keywords: COVID-19; Cardiovascular system.

PubMed Disclaimer

Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no conflicts of interest concerning this article. Dr Fauvel reports grants from Pfizer and consulting fees from Janssen, outside the submitted work. Prof Cohen acknowledges the following without any relationship to the current manuscript: research grant from RESICARD (research nurses); and consultant and lecture fees from the companies Amgen, AstraZeneca, Bayer Pharma, Alliance BMS- Pfizer, Novartis, and Sanofi-Aventis.

Figures

Fig 1 — **Fig. 1**
Central Illustration. Cardiovascular manifestations secondary to COVID-19.Abbreviations: ICU: intensive cardiac unit, LV: left ventricular, CV: cardiovascular.

See this image and copyright information in PMC

Cited by

Clustering of clinical and echocardiographic phenotypes of covid-19 patients.
Shpigelman E, Hochstadt A, Coster D, Merdler I, Ghantous E, Szekely Y, Lichter Y, Taieb P, Banai A, Sapir O, Granot Y, Lupu L, Borohovitz A, Sadon S, Banai S, Rubinshtein R, Topilsky Y, Shamir R. Shpigelman E, et al. Sci Rep. 2023 May 31;13(1):8832. doi: 10.1038/s41598-023-35449-1. Sci Rep. 2023. PMID: 37258639 Free PMC article.
In Vitro Evidence of Statins' Protective Role against COVID-19 Hallmarks.
Fiore D, Proto MC, Franceschelli S, Pascale M, Bifulco M, Gazzerro P. Fiore D, et al. Biomedicines. 2022 Aug 29;10(9):2123. doi: 10.3390/biomedicines10092123. Biomedicines. 2022. PMID: 36140223 Free PMC article.
COVID-19 infection and longevity: an observational and mendelian randomization study.
Qiu S, Liu J, Guo J, Zhang Z, Guo Y, Hu Y. Qiu S, et al. J Transl Med. 2025 Mar 6;23(1):283. doi: 10.1186/s12967-024-05932-y. J Transl Med. 2025. PMID: 40050903 Free PMC article.
Autopsies Revealed Pathological Features of COVID-19 in Unvaccinated vs. Vaccinated Patients.
Colombo D, Del Nonno F, Marchioni L, Lalle E, Gallì P, Vaia F, Falasca L. Colombo D, et al. Biomedicines. 2023 Feb 14;11(2):551. doi: 10.3390/biomedicines11020551. Biomedicines. 2023. PMID: 36831087 Free PMC article.

References

1. Shi S., Qin M., Shen B., Cai Y., Liu T., Yang F., et al. Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China. JAMA Cardiol. 2020;5(7):802–810. - PMC - PubMed
1. World Health Organization. Corona- virus disease (COVID-19) outbreak (https://www.who.int).
1. Yang X., Yu Y., Xu J., Shu H., Xia J., Liu H., et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir. Med. 2020;8(5):475–481. - PMC - PubMed
1. Huang C., Wang Y., Li X., Ren L., Zhao J., Hu Y., et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497–506. - PMC - PubMed
1. Xu Z., Shi L., Wang Y., Zhang J., Huang L., Zhang C., et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir. Med. 2020;8(4):420–422. - PMC - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions

LinkOut - more resources

Full Text Sources
Medical
- MedlinePlus Health Information

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Cardiovascular manifestations secondary to COVID-19: A narrative review

Affiliations

Cardiovascular manifestations secondary to COVID-19: A narrative review

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Medical