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. 2022 May 4:77:100040.
doi: 10.1016/j.clinsp.2022.100040. eCollection 2022.

L1 cell adhesion molecule high expression is associated with poor prognosis in surgically resected brain metastases from lung adenocarcinoma

Jia-Wei Wang  1 , Song-Quan Wang  1 , Zhuo-Yi Wu  1 , Qi Liu  1 , Qing Yuan  2 , Hong-Qing Cai  3 , Jing-Hai Wan  4
Affiliations

L1 cell adhesion molecule high expression is associated with poor prognosis in surgically resected brain metastases from lung adenocarcinoma

Jia-Wei Wang et al. Clinics (Sao Paulo). .

Abstract

Objectives: Accurate prognosis assessment across the heterogeneous population of brain metastases is very important, which may facilitate clinical decision-making and appropriate stratification of future clinical trials. Previous studies have shown the L1 Cell Adhesion Molecule (L1CAM) is potentially involved in human malignancies of multiple different samples and unfavorable survival. However, no data of L1CAM are available for the brain metastases from lung adenocarcinoma, especially for the one with neurosurgical resection.

Method: The authors investigated the L1CAM expression in cranial metastatic lesions for patients with brain metastases from lung adenocarcinoma after neurosurgical resection using tissue microarrays that were obtained from the Department of Neurosurgery at the Cancer Hospital of the Chinese Academy of Medical Sciences. Furthermore, the relationship between L1CAM expression and clinic-pathological parameters, including overall survival time, was analyzed to assess the prognostic value of L1CAM.

Results: L1CAM high expression was found in 62.30% of brain metastases from lung adenocarcinoma and significantly correlated with brain metastasis number (p = 0.028) and Lung-molGPA score (p = 0.042). Moreover, L1CAM expression was an independent predictor of survival for brain metastases after neurosurgical resection in a multivariate analysis. Patients with L1CAM high expression had unfavorable overall survival time (p = 0.016). In addition, the multivariate analysis also showed age and extracranial transfer were also the independent prognostic factors for this type of patient with brain metastases.

Conclusions: A subset of brain metastases from lung adenocarcinoma aberrantly expresses L1CAM. L1CAM is a novel independent prognostic factor for brain metastasis from lung adenocarcinoma after neurosurgical resection.

Keywords: Brain metastasis from lung cancer; L1 cell adhesion molecule; Neurosurgical resection; Prognostic factor.

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Conflict of interest statement

Conflicts of interest This work was supported by grants from Beijing Xisike Clinical Oncology Research Foundation (Y-QL202101-0094), National Natural Science Foundation of China (82072803) and CAMS Innovation Fund for Medical Sciences (2021-I2M-1-012).

Figures

Fig 1
Fig. 1
Typical L1CAM stained images on TMA section of brain metastases from lung adenocarcinoma, including negative, mild, moderate, and strong staining. L1CAM, L1 Cell Adhesion Molecule; TMA, Tissue Microarray.
Fig 2
Fig. 2
Kaplan-Meier curves showing survival time by clinic-pathological parameters for surgically resected brain metastases from lung adenocarcinoma. L1CAM high expression (L) was associated with unfavorable survival time. L1CAM, L1 Cell Adhesion Molecule.
See this image and copyright information in PMC

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