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Review
. 2022 Aug;50(8):898-913.
doi: 10.1007/s10439-022-02970-9. Epub 2022 May 7.

Effect of Angiogenesis in Bone Tissue Engineering

Jianhao Huang  1 , Qixiu Han  2 , Meng Cai  3 , Jie Zhu  2 , Lan Li  4 , Lingfeng Yu  5 , Zhen Wang  2 , Gentao Fan  6 , Yan Zhu  6 , Jingwei Lu  7   8 , Guangxin Zhou  9   10   11   12
Affiliations
Review

Effect of Angiogenesis in Bone Tissue Engineering

Jianhao Huang et al. Ann Biomed Eng. 2022 Aug.

Abstract

The reconstruction of large skeletal defects is still a tricky challenge in orthopedics. The newly formed bone tissue migrates sluggishly from the periphery to the center of the scaffold due to the restrictions of exchange of oxygen and nutrition impotent cells osteogenic differentiation. Angiogenesis plays an important role in bone reconstruction and more and more studies on angiogenesis in bone tissue engineering had been published. Promising advances of angiogenesis in bone tissue engineering by scaffold designs, angiogenic factor delivery, in vivo prevascularization and in vitro prevascularization are discussed in detail. Among all the angiogenesis mode, angiogenic factor delivery is the common methods of angiogenesis in bone tissue engineering and possible research directions in the future.

Keywords: Angiogenesis; Bone tissue engineering; Cell engineering; Materials properties.

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