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Comment
. 2022 May 7;7(1):153.
doi: 10.1038/s41392-022-01011-0.

Suicide signaling by GSDMA: a single-molecule mechanism for recognition and defense against SpeB-expressing GAS

Judit Symmank  1 , Collin Jacobs  2 , Ulrike Schulze-Späte  3
Affiliations
Comment

Suicide signaling by GSDMA: a single-molecule mechanism for recognition and defense against SpeB-expressing GAS

Judit Symmank et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The author declares no competing interests.

Figures

Fig. 1
Fig. 1
GSDMA-driven pyroptosis of epithelial cells as a single-molecule mechanism for detection and elimination of SpeB-expressing Streptococcus pyrogenes. Following pathogen invasion, caspase 1-independent activation of the gasdermin GSDMA occurs via direct proteolytic cleavage by SpeB. Subsequent GSDMA pore formation in the host cell membrane promote pyroptosis of the infected cells, ultimately leading to local inflammation and elimination of the pathogen. Gsdma1 deficiency and SpeB mutation/inhibition fail to result in activated GSDMA and thus the local immune response, resulting in systemic dissemination and infection of multiple organs. SpeB protein structure was designed by Universal Protein Resource (UniProtKB accession number P0C0J0)
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References

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