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. 2022 May 8;8(1):89.
doi: 10.1186/s40792-022-01446-1.

Laparoscopic distal gastrectomy for synchronous adenocarcinoma, diffuse large B cell lymphoma and gastrointestinal stromal tumor in the stomach: a case report

Toshiyasu Ojima  1 , Hirotaka Tabata  2 , Hiroki Yamaue  2
Affiliations

Laparoscopic distal gastrectomy for synchronous adenocarcinoma, diffuse large B cell lymphoma and gastrointestinal stromal tumor in the stomach: a case report

Toshiyasu Ojima et al. Surg Case Rep. .

Abstract

Background: Synchronous lymphoma and adenocarcinoma are occasionally detected in the stomach. Gastrointestinal stromal tumor (GIST) and adenocarcinoma are sometimes seen simultaneously in the stomach. However, we rarely observe synchronous adenocarcinoma, lymphoma, and GIST in the stomach, and there are few reports on cases with these three lesions.

Case presentation: This is a case report of a 71-year-old man who had a laparoscopic distal gastrectomy and lymphadenectomy for three gastric tumors. Preoperative diagnoses were early adenocarcinoma and mucosa-associated lymphoid tissue (MALT) lymphoma in the stomach, but final diagnosis was synchronous adenocarcinoma, diffuse large B cell lymphoma (DLBCL), and GIST. Helicobacter pylori (H. pylori) is highly involved in the development of DLBCL and MALT lymphoma in the stomach. Gastric adenocarcinoma is partially involved in chronic gastritis with atrophy and intestinal metaplasia caused by H. pylori infection. Indeed, a rapid urease test was found positive in this case. Therefore, we prescribed medicine to eliminate H. pylori after gastrectomy.

Conclusion: This is the first case report where a patient underwent minimally invasive laparoscopic gastrectomy for synchronous adenocarcinoma, DLBCL and GIST in the stomach, although one patient who underwent open gastrectomy for synchronous adenocarcinoma, MALT lymphoma and GIST was previously reported.

Keywords: Adenocarcinoma; Diffuse large B cell lymphoma; Gastrointestinal stromal tumor.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Computed tomography scan. Yellow arrows show the gastric wall thickness in the lower gastric body. A Gastric cancer, B lymphoma
Fig. 2
Fig. 2
Gastrointestinal endoscopy findings. A Lymphoma, B gastric cancer, C submucosal tumor
Fig. 3
Fig. 3
Resected specimen. Blue arrow shows the gastric cancer. Yellow arrow shows the lymphoma. Red arrow shows the submucosal tumor
Fig. 4
Fig. 4
Histological findings. A Poorly differentiated adenocarcinoma infiltrating into deep submucosa (hematoxylin–eosin: × 100). B Diffuse large B cell lymphoma tissue containing large atypical lymphocytes immunostaining for CD20 (× 200). C Gastrointestinal stromal tumor tissue containing with spindle, sharp and atypical cell immunostaining for c-kit (× 100)
See this image and copyright information in PMC

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References

    1. Kafes A, Hughes L, Hollinshead J, Katelaris P. Synchronous primary adenocarcinoma, mucosa-associated lymphoid tissue lymphoma and a stromal tumor in a helicobacter pylori-infected stomach. J Gastroenterol Hepatol. 2002;17:1033–1036. doi: 10.1046/j.1440-1746.2002.02649.x. - DOI - PubMed
    1. Salar A, Ramon JM, Barranco C, Nieto M, Prats M, Serrano S, et al. Double diagnosis in cancer patients and cutaneous reaction related to gemcitabine: CASE 1. Synchronous mucosa associated lymphoid tissue lymphoma and gastrointestinal stromal tumors of the stomach. J Clin Oncol. 2005;23:7221–7223. doi: 10.1200/JCO.2005.08.158. - DOI - PubMed
    1. Pamukçuoglu M, Budakoğlu B, Han O, Tad M, Oksüzoğlu B, Abali H, et al. An extraordinary case in whom gastrointestinal stromal tumor and low-grade malignant lymphoma are seen together in the stomach. Med Oncol. 2007;24:351–353. doi: 10.1007/s12032-007-0001-4. - DOI - PubMed
    1. Wotherspoon A, Doglioni C, Diss TC, Pan L, Moschini A, de Boni M, et al. Regression of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue after eradication of Helicobacter pylori. Lancet. 1993;342:575–577. doi: 10.1016/0140-6736(93)91409-F. - DOI - PubMed
    1. Starostik P, Patzner J, Greiner A, Schwarz S, Kalla J, Ott G, et al. Gastric marginal zone B-cell lymphomas of MALT type develop along 2 distinct pathogenetic pathways. Blood. 2002;99:3–9. doi: 10.1182/blood.V99.1.3. - DOI - PubMed

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