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Comment
. 2022 Jun;43(6):423-425.
doi: 10.1016/j.it.2022.04.004. Epub 2022 May 5.

The extracellular matrix and immunity: breaking the old barrier in cancer

Maulik Vyas  1 , Shadmehr Demehri  2
Affiliations
Comment

The extracellular matrix and immunity: breaking the old barrier in cancer

Maulik Vyas et al. Trends Immunol. 2022 Jun.

Abstract

Extracellular matrix (ECM) is an integral component of solid cancers; however, the impact of the ECM on antitumor immunity has remained elusive. Sun and colleagues now demonstrate that discoidin domain receptor 1-mediated collagen assembly can exclude T cells from tumors. Together, recent studies highlight ECM as an active regulator of immunity in cancer.

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Conflict of interest statement

Declaration of interests None declared by authors.

Comment on

  • Tumour DDR1 promotes collagen fibre alignment to instigate immune exclusion.
    Sun X, Wu B, Chiang HC, Deng H, Zhang X, Xiong W, Liu J, Rozeboom AM, Harris BT, Blommaert E, Gomez A, Garcia RE, Zhou Y, Mitra P, Prevost M, Zhang D, Banik D, Isaacs C, Berry D, Lai C, Chaldekas K, Latham PS, Brantner CA, Popratiloff A, Jin VX, Zhang N, Hu Y, Pujana MA, Curiel TJ, An Z, Li R. Sun X, et al. Nature. 2021 Nov;599(7886):673-678. doi: 10.1038/s41586-021-04057-2. Epub 2021 Nov 3. Nature. 2021. PMID: 34732895 Free PMC article.

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