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Comment
. 2022 Jun;43(6):415-416.
doi: 10.1016/j.it.2022.04.006. Epub 2022 May 5.

CD8+ Tregs kill pathogenic cells to avert autoimmunity

Dan Hu  1 , Gopal Murugaiyan  2
Affiliations
Comment

CD8+ Tregs kill pathogenic cells to avert autoimmunity

Dan Hu et al. Trends Immunol. 2022 Jun.

Abstract

Mouse Ly49+CD8+ regulatory T cells (Tregs) can subdue autoreactive CD4+ T cells to suppress autoimmunity. Recently, Li et al. demonstrated that killer-cell immunoglobulin-like receptor (KIR)+CD8+ T cells are the human equivalent of Ly49+CD8+ regulatory T cells and kill pathogenic CD4+ T cells, which can be increased in certain human autoimmune diseases and viral infections.

Keywords: CD8(+) Tregs; T cells; autoimmunity.

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Conflict of interest statement

Declaration of interests The authors declare no conflicts of interest.

Comment on

  • KIR+CD8+ T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19.
    Li J, Zaslavsky M, Su Y, Guo J, Sikora MJ, van Unen V, Christophersen A, Chiou SH, Chen L, Li J, Ji X, Wilhelmy J, McSween AM, Palanski BA, Mallajosyula VVA, Bracey NA, Dhondalay GKR, Bhamidipati K, Pai J, Kipp LB, Dunn JE, Hauser SL, Oksenberg JR, Satpathy AT, Robinson WH, Dekker CL, Steinmetz LM, Khosla C, Utz PJ, Sollid LM, Chien YH, Heath JR, Fernandez-Becker NQ, Nadeau KC, Saligrama N, Davis MM. Li J, et al. Science. 2022 Apr 15;376(6590):eabi9591. doi: 10.1126/science.abi9591. Epub 2022 Apr 15. Science. 2022. PMID: 35258337 Free PMC article.