The endothelium of the high endothelial venule: a specialized endothelium with unique properties
- PMID: 3552777
- DOI: 10.1159/000163388
The endothelium of the high endothelial venule: a specialized endothelium with unique properties
Abstract
High endothelial venules (HEV) in lymphoid organs are specialized to facilitate the passage of lymphocytes into lymphoid parenchyma. This is accomplished by a ligand-receptor system on the endothelium and lymphocytes, which differs between lymph nodes and Peyer's patch. Experiments discussed in this paper show that other non-HEV-derived endothelial cells can acquire the characteristics of HEV and that HEV may differentiate under influences from their local micro-environments.
Similar articles
-
Immunohistologic and functional characterization of a vascular addressin involved in lymphocyte homing into peripheral lymph nodes.J Cell Biol. 1988 Nov;107(5):1853-62. doi: 10.1083/jcb.107.5.1853. J Cell Biol. 1988. PMID: 2460470 Free PMC article.
-
Involvement of sialic acid on endothelial cells in organ-specific lymphocyte recirculation.Science. 1985 May 24;228(4702):1005-7. doi: 10.1126/science.4001928. Science. 1985. PMID: 4001928
-
Organ specificity of lymphocyte migration: mediation by highly selective lymphocyte interaction with organ-specific determinants on high endothelial venules.Eur J Immunol. 1980 Jul;10(7):556-61. doi: 10.1002/eji.1830100713. Eur J Immunol. 1980. PMID: 6157544
-
Specific lymphocyte-endothelial cell interactions regulate migration into lymph nodes, Peyer's patches, and skin.Reg Immunol. 1988 Jul-Aug;1(1):78-83. Reg Immunol. 1988. PMID: 3079311 Review.
-
Lymphocyte homing receptors.Cell. 1986 Mar 14;44(5):673-80. doi: 10.1016/0092-8674(86)90832-9. Cell. 1986. PMID: 3004743 Review. No abstract available.
Cited by
-
High endothelial differentiation in human lymphoid and inflammatory tissues defined by monoclonal antibody HECA-452.Am J Pathol. 1988 Jan;130(1):147-55. Am J Pathol. 1988. PMID: 3276207 Free PMC article.
-
Lymphocyte migration into the lamina propria of the gut is mediated by specialized HEV-like blood vessels.Immunology. 1987 Oct;62(2):273-7. Immunology. 1987. PMID: 3315979 Free PMC article.
-
The localization of macrophage subsets and dendritic cells in the gastrointestinal tract of the mouse with special reference to the presence of high endothelial venules. An immuno- and enzyme-histochemical study.Cell Tissue Res. 1990 Mar;259(3):587-93. doi: 10.1007/BF01740787. Cell Tissue Res. 1990. PMID: 2180576
-
Interferon-gamma-increased adherence of lymphocytes to high endothelial venules.Immunology. 1989 Oct;68(2):221-6. Immunology. 1989. PMID: 2509328 Free PMC article.
-
Ultrastructural pathology of the 'barrier sites' in experimental autoimmune uveitis and experimental autoimmune pinealitis.Br J Ophthalmol. 1991 Jul;75(7):391-7. doi: 10.1136/bjo.75.7.391. Br J Ophthalmol. 1991. PMID: 1854690 Free PMC article.