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. 2021 Dec 9;8(2):160-167.
doi: 10.1159/000520586. eCollection 2022 Mar.

History of Adverse Pregnancy on Subsequent Maternal-Fetal Outcomes in Patients with Immunoglobulin A Nephropathy: A Retrospective Cohort Study from a Chinese Single Center

Xingji Lian  1   2   3 , Li Fan  1   2   3 , Xin Ning  1   2   3 , Cong Wang  1   2   3 , Yi Lin  1   2   3 , Wenfang Chen  4 , Wei Chen  1   2   3 , Xueqing Yu  1   2   3
Affiliations

History of Adverse Pregnancy on Subsequent Maternal-Fetal Outcomes in Patients with Immunoglobulin A Nephropathy: A Retrospective Cohort Study from a Chinese Single Center

Xingji Lian et al. Kidney Dis (Basel). .

Erratum in

  • Erratum.
    [No authors listed] [No authors listed] Kidney Dis (Basel). 2025 May 26;11(1):319. doi: 10.1159/000546078. eCollection 2025 Jan-Dec. Kidney Dis (Basel). 2025. PMID: 40421436 Free PMC article.

Abstract

Background: Gestation complications have a recurrence risk and could predispose to each other in the next pregnancy. We aimed to evaluate the relationship between a history of adverse pregnancy and maternal-fetal outcomes in subsequent pregnancy in patients with Immunoglobulin A nephropathy (IgAN).

Methods: A retrospective cohort study from a Chinese single center was conducted. Pregnant women with biopsy-proven primary IgAN and aged ≥18 years were enrolled and divided into the 2 groups by a history of adverse pregnancy. The primary outcome was adverse pregnancy outcome, which included maternal-fetal outcomes. Logistical regression model was used to evaluate the association of a history of adverse pregnancy with subsequent adverse maternal and fetal outcomes.

Results: Ninety-one women with 100 pregnancies were included, of which 54 (54%) pregnancies had a history of adverse pregnancy. IgAN patients with adverse pregnancy history had more composite maternal outcomes (70.4% vs. 45.7%, p = 0.012), while there was no difference in the composite adverse fetal outcomes between the 2 groups (55.6% vs. 45.7%). IgAN patients with a history of adverse pregnancy were associated with an increased risk of subsequent adverse maternal outcomes (adjusted odds ratio [OR], 2.64; 95% CI, 1.07-6.47). Similar results were shown in those with baseline serum albumin <3.5 g/dL, 24 h proteinuria ≥1 g/day, and a history of hypertension. There was no association between a history of adverse pregnancy and subsequent adverse fetal outcomes in IgAN patients (adjusted OR, 1.56; 95% CI, 0.63-3.87).

Conclusion: A history of adverse pregnancy was associated with an increased risk of subsequent adverse maternal outcomes, but not for adverse fetal outcomes in IgAN patients.

Keywords: Chronic kidney disease; Immunoglobulin A nephropathy; Kidney disease outcome; Pregnancy outcome.

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Conflict of interest statement

The results presented in this article have not been published previously except in abstract form. The authors declare no relevant conflicts of interest. Co-author Xueqing Yu is an Editorial Board Member of Kidney Diseases.

Figures

Fig. 1
Fig. 1
Subgroup analysis of a history of adverse pregnancy with fetal and maternal outcomes. GFR, glomerular filtration rate; eGFR, estimated glomerular filtration rate.
Fig. 2
Fig. 2
Changes in eGFR (a) and protein urine (b) at the time of kidney biopsy, during delivery and after delivery. eGFR, estimated glomerular filtration rate.
See this image and copyright information in PMC

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