Association of Low Expression of NUMB in Peripheral Blood with Acute Myocardial Infarction

Abstract

Objective: Our study's goal was to find out acute myocardial infarction (AMI) patients' NUMB gene expression patterns and to evaluate its role as a diagnostic marker for AMI detection.

Methods: Peripheral blood was drawn from 124 individuals who had an AMI and 115 patients who had stable coronary artery disease (SCAD). The real-time quantitative polymerase chain reaction was used to measure the mRNA expression level of the NUMB gene in peripheral blood.

Results: The AMI group's NUMB gene expression was 0.906 (0.181-0.954), whereas the SCAD group's expression was 1.024 (0.207-1.127). However, the AMI group had 0.885 times lower NUMB mRNA expression than the SCAD group (P < 0.05).

Conclusion: Multivariate logistic regression evaluation found that lower NUMB expression was correlated with an increased risk of coronary artery disease. However, age and fasting plasma glucose levels were not associated with decreased NUMB expression.

Figure 1

Schematic diagram depicting the research technology route. See research subjects and methods for details.

Figure 2

Relative expression of NUMB gene mRNA. The abscissa is a grouping, the ordinate is a relative expression, and the ordinate is an unequal distance coordinate. AMI, acute myocardial infarction.