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Review
. 2022 Apr 29:2022:1086697.
doi: 10.1155/2022/1086697. eCollection 2022.

A Clinical Analysis and Literature Review of Six Cases with Primary Pulmonary Lymphoepithelioma-Like Carcinoma

Lingyan Ye  1 , Dinghai Luo  2 , Haiyan Li  1 , Haihong Zheng  3 , Susu He  1 , Ling Lin  1 , Yicheng Fang  4 , Junhui Ye  5 , Chengshui Chen  6
Affiliations
Review

A Clinical Analysis and Literature Review of Six Cases with Primary Pulmonary Lymphoepithelioma-Like Carcinoma

Lingyan Ye et al. Comput Math Methods Med. .

Retraction in

Abstract

Methods: The clinical data of six patients with primary pulmonary lymphoepithelioma-like carcinoma treated in Zhejiang Taizhou Hospital of Taizhou Enze Medical Center (Group) from May 2014 to December 2018 were summarized and analyzed. Combined with the relevant literature, the primary pulmonary lymphoepithelioma-like carcinoma was analyzed retrospectively.

Results: The main manifestations of six patients were respiratory symptoms, and cough was the most common. The imaging features of six patients were mainly round-like high-density mass shadow or nodule shadow. All patients were diagnosed by pathology. Microscopically, the cancer cells were nested, with large nuclei and vacuoles and abundant lymphocyte infiltration in the tumor stroma. The positive rates of EBER, p63, CK5/6, and Ki-67 were high, and TTF-1 was negative. Five patients received surgical treatment. One patient developed brain metastasis 12 months after operation and received craniocerebral radiotherapy. The other patients did not receive radiotherapy and chemotherapy, and one patient did not receive treatment. After follow-up, four patients survived so far, the longest survival time was 82 months, one patient lost follow-up, and one patient died of lung metastasis 24 months after operation.

Conclusion: Primary pulmonary lymphoepitheliomatoid-like carcinoma is a rare lung malignant tumor, whose pathogenesis is related to Epstein-Barr virus infection. The clinical manifestations are nonspecific, but with unique pathological characteristics. Surgical resection is the proper treatment for early-stage patients, and comprehensive treatment with surgery as the main treatment is suitable for late-stage patients. The prognosis is good.

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Conflict of interest statement

We declare no conflict of interests.

Figures

Figure 1
Figure 1
The soft tissue mass in the right upper lobe of the lung has clear boundary, uneven density, and vascular invasion, with intrapulmonary and pleural metastasis.
Figure 2
Figure 2
The nodule in the right lower lobe of lung, with clear margin.
Figure 3
Figure 3
The nodule in the right middle lobe of the lung, with shallow lobulated.
Figure 4
Figure 4
In diffuse lymphocytes, the cancer cells are arranged in nests and scattered, oval or polygonal, with large, vacuolar nuclei and prominent nucleoli (high magnification with HE staining).
Figure 5
Figure 5
Eber in situ hybridization positive (in situ hybridization low magnification).
See this image and copyright information in PMC

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