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Review
. 2022;12(3):994-1001.
doi: 10.1007/s12668-022-00977-z. Epub 2022 May 4.

Perspectives on the Use of Small Noncoding RNAs as a Therapy for Severe Virus-Induced Disease Manifestations and Late Complications

Oxana V Klimenko  1
Affiliations
Review

Perspectives on the Use of Small Noncoding RNAs as a Therapy for Severe Virus-Induced Disease Manifestations and Late Complications

Oxana V Klimenko. Bionanoscience. 2022.

Abstract

Many viruses appear each year. Some of these viruses result in severe disease and even death. The frequency of epidemics and pandemics is growing at an alarming rate. The lack of virus-specific etiopathogenic drugs necessitates the search for new tools for the complex treatment of severe viral diseases and their late complications. Small noncoding RNAs and their antagonists may be effective therapeutic tools for preventing virus-induced damage to targeted epithelial cells and surrounding tissues in the manifestation stage. Moreover, sncRNAs could interfere with the virus-interacting host genes that trigger the malignant transformation of target cells as a late complication of severe viral diseases.

Keywords: ARDS; COVID-19; Cancer; SARS-CoV-2; Small noncoding RNAs.

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Conflict of interest statement

Conflict of InterestThe author declares no competing interests.

Figures

Fig. 1
Fig. 1
The use of the sncRNAs/DDMC complex as an antiviral therapeutic tool. The DDMC polymer vector is a carrier for sncRNAs or antago-miRs. It protects active RNAs from biodegradation in blood and cells. The complex of sncRNAs and DDMC slowly decays in the cytoplasm, releasing sncRNAs or their antago-miRs. SncRNAs induce RNA interference mechanisms. The effects and mechanisms regulated by miR-155 and antago-miR-155 in virus-targeted cells are associated with severe viral manifestations and late complications
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