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Review
. 2022 Dec:151:451-483.
doi: 10.1016/j.sajb.2022.04.053. Epub 2022 May 2.

Phytomedicines explored under in vitro and in silico studies against coronavirus: An opportunity to develop traditional medicines

Yashika Gandhi  1 , Sujeet K Mishra  1 , Hemant Rawat  1 , Jyotika Grewal  1 , Ravi Kumar  1 , Santosh K Shakya  1 , Vipin Kumar Jain  1 , G Babu  2 , Arjun Singh  3 , Ravindra Singh  3 , Rabinarayan Acharya  3 , Vijay Kumar  1
Affiliations
Review

Phytomedicines explored under in vitro and in silico studies against coronavirus: An opportunity to develop traditional medicines

Yashika Gandhi et al. S Afr J Bot. 2022 Dec.

Abstract

The widespread COVID-19 pandemic, caused by novel coronavirus SARS-CoV-2, has emanated as one of the most life-threatening transmissible diseases. Currently, the repurposed drugs such as remdesivir, azithromycine, chloroquine, and hydroxychloroquine are being employed in the management of COVID-19 but their adverse effects are a matter of concern. In this regard, alternative treatment options i.e., traditional medicine, medicinal plants, and their phytochemicals, which exhibit significant therapeutic efficacy and show a low toxicity profile, are being explored. The current review aims at unraveling the promising medicinal plants, phytochemicals, and traditional medicines against SARS-CoV-2 to discover phytomedicines for the management of COVID-19 on the basis of their potent antiviral activities against coronaviruses, as demonstrated in various biochemical and computational chemical biology studies. The review consists of integrative and updated information on the potential traditional medicines against COVID-19 and will facilitate researchers to develop traditional medicines for the management of COVID-19.

Keywords: Ayurveda; COVID-19; Coronavirus; Phytochemicals; Traditional medicines.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig 1
Fig. 1
Structure of SARS-CoV-2.
Fig 2
Fig. 2
Pathogenesis of COVID-19.
Fig 3
Fig. 3
A schematic representation illustrating the role of phytochemicals in interfering with the pathogenesis of COVID-19.
See this image and copyright information in PMC

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References

    1. Agarwal R., Diwanay S., Patki P., Patwardhan B. Studies on immunomodulatory activity of Withaniasomnifera (Ashwagandha) extracts in experimental immune inflammation. J. Ethnopharmacol. 1999;67:27–35. doi: 10.1016/S0378-8741(99)00065-3. - DOI - PubMed
    1. Ahmad S., Zahiruddin S., Parveen B., Basist P., Parveen A., Gaurav Parveen R., Ahmad M. Indian medicinal plants and formulations and their potential against COVID-19–preclinical and clinical research. Front. Pharmacol. 2021;11 doi: 10.3389/fphar.2020.578970. - DOI - PMC - PubMed
    1. Akram M., Tahir I.M., Shah S.M.A., Mahmood Z., Altaf A., Ahamd K., Munir N., Daniyal M., Nasir S., Mehboob H. Antiviral potential of medicinal plants against HIV, HSV, influenza, hepatitis, and coxsackievirus: a systematic review. Phytother. Res. 2018;32:811–822. doi: 10.1002/ptr.6024. - DOI - PubMed
    1. Amoros M., Fauconnier B., Girre R.L. In vitro antiviral activity of a saponin from Anagallis arvensis, Primulaceae, against herpes simplex virus and poliovirus. Antiviral Res. 1987;8:13–25. doi: 10.1016/0166-3542(87)90084-2. - DOI - PubMed
    1. Anand A.V., Balamuralikrishnan B., Kaviya M., Bharathi K., Parithathvi A., Arun M., Senthilkumar N., Velayuthaprabhu S., Saradhadevi M., Al-Dhabi N.A., Arasu M.V., Yatoo M.I., Tiwari R., Dhama K. Medicinal plants, phytochemicals, and herbs to combat viral pathogens including sars-cov-2. Molecules. 2021;26:1775. doi: 10.3390/molecules26061775. - DOI - PMC - PubMed

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