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Review
. 2022 Apr 15;12(4):1456-1464.
eCollection 2022.

The role of Fbxo5 in the development of human malignant tumors

Junjie Gao  1 , Dandan Yang  1 , Ruoxue Cao  2 , Hua Huang  3 , Jia Ma  3 , Zhiwei Wang  3 , Jun Xia  3 , Xueshan Pan  3
Affiliations
Review

The role of Fbxo5 in the development of human malignant tumors

Junjie Gao et al. Am J Cancer Res. .

Abstract

Fbxo5 (F-Box only protein 5), as a substrate recognition subunit of SCF (SKP1-Cullin1-Fbox) protein, plays a crucial role in various cellular processes through ubiquitination and degradation of multiple proteins. In recent years, many studies have pointed out that Fbxo5 is critically involved in carcinogenesis. Moreover, targeting Fbxo5 could have a therapeutic potential for cancer therapy. This review focuses on the functions of Fbxo5 in various types of human malignancies and its underlying molecular mechanisms. This review might lay the foundation for enhancing future investigation on Fbxo5 functions in cancer development and progression.

Keywords: APC/C; F-box family protein; Fbxo5; SCF; cancer.

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Conflict of interest statement

None.

Figures

Figure 1
Figure 1
Fbxo5 expression levels in different cancer tissues and corresponding normal tissues are illustrated.
See this image and copyright information in PMC

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