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Review
. 2022 Apr 21:12:885214.
doi: 10.3389/fonc.2022.885214. eCollection 2022.

The Biological Functions and Clinical Values of Exosomal Circular RNAs in Hepatocellular Carcinoma

Ying Zhao  1 , Jinmei Yao  1
Affiliations
Review

The Biological Functions and Clinical Values of Exosomal Circular RNAs in Hepatocellular Carcinoma

Ying Zhao et al. Front Oncol. .

Abstract

Hepatocellular carcinoma (HCC) exacts a heavy disease burden and is currently the second most common cause of cancer-related deaths worldwide. HCC usually lacks obvious symptoms in the early stage, and most HCC patients are diagnosed at advanced stages with poor prognosis. Circular RNAs (circRNAs) are single-stranded RNAs that form covalently closed loops and are stable in exosomes. Exosomes are known as important messengers of the cross-talk between tumor and immune cells. Accumulating studies have demonstrated the promoter or suppressor roles of exosomal circRNAs in the carcinogenesis, progression, and metastasis of HCC. In this review, we summarized the current studies on the biological functions and diagnostic and prognostic values of exosomal circRNAs in HCC progression.

Keywords: circRNAs; exosome; hepatocellular carcinoma; metastasis; prognosis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Representation of main biological functions of dysregulated exosomal circRNAs in HCC.
See this image and copyright information in PMC

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