Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1987;83(1):109-11.
doi: 10.1159/000234340.

Presence of Ia-positive cells in the central nervous system of the rat during various pathological conditions

C H Polman, C D Dijkstra, C J de Groot, J C Koetsier, T Sminia

Presence of Ia-positive cells in the central nervous system of the rat during various pathological conditions

C H Polman et al. Int Arch Allergy Appl Immunol. 1987.

Abstract

The rat central nervous system (CNS) was analyzed immunohistochemically during various pathological conditions by using monoclonal antibodies specific for rat T lymphocytes, rat macrophages and Ia antigen. It was found that in immunologically mediated disease infiltrating macrophages do express the Ia antigen, whereas in nonimmunologically mediated disease they do not. The results suggest that based on the composition of the mononuclear phagocyte infiltrate a clear distinction can be made between different inflammatory reaction types within the CNS.

PubMed Disclaimer

MeSH terms

Substances