Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2022 Apr 4;14(4):e23819.
doi: 10.7759/cureus.23819. eCollection 2022 Apr.

A Rare Case of Solitary Plasmacytoma Arising From the Sternum

Nyan Bethel  1 , Henna Asrar  1 , Jenna Dacosta  1 , Andreas Savopoulos  2 , Hamid Shaaban  2
Affiliations
Case Reports

A Rare Case of Solitary Plasmacytoma Arising From the Sternum

Nyan Bethel et al. Cureus. .

Abstract

Solitary plasmacytoma (SP) is characterized by an accumulation of neoplastic monoclonal plasma cells in a localized fashion, without evidence of multiple myeloma. It makes up <5% of all plasma cell neoplasms and is typically found in regions like the pelvis, ribs, vertebra, and spine. SP is classified into extramedullary plasmacytoma (EMP), which primarily affects soft tissues, and solitary bone plasmacytoma (SBP), which primarily affects the pelvis, ribs, vertebrae, and spine. We report a case of a 66-year-old man with sternal plasmacytoma presenting as chest pain. He was treated with radiation therapy. Here, we aim to describe the clinical features, diagnostic methods, treatment, and potential outcome in a patient with SBP.

Keywords: extramedullary plasmacytoma; multiple myeloma; plasma cells; solitary bone plasmacytoma; solitary plasmacytoma; sternum.

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Axial computed tomography (CT) image of an osteolytic sternal mass
Figure 2
Figure 2. Sagittal computed tomography view of the sternal mass
Figure 3
Figure 3. Immunohistochemical stain (CD138) on sternal biopsy specimen revealing plasma cells (60x)
Figure 4
Figure 4. Bone marrow biopsy revealed minimal marrow involvement (H&E stain, 60x)
See this image and copyright information in PMC

References

    1. Solitary plasmacytoma of bone and asymptomatic multiple myeloma. Dimopoulos M, Moulopoulos L, Maniatis A, et al. Mendeley. 2000;6:2037–2044. - PubMed
    1. Diagnosis, treatment, and response assessment in solitary plasmacytoma: updated recommendations from a European Expert Panel. Caers J, Paiva B, Zamagni E, et al. J Hematol Oncol. 2018;11:10. - PMC - PubMed
    1. A review for solitary plasmacytoma of bone and extramedullary plasmacytoma. Kilciksiz S, Karakoyun-Celik O, Agaoglu FY, Haydaroglu A. Sci World J. 2012;2012:895765. - PMC - PubMed
    1. Solitary plasmacytoma of the occipital bone: a case report. Wang L, Ren N, Cai H, et al. J Int Med Res. 2020;48:1–7. - PMC - PubMed
    1. Radiation therapy for the solitary plasmacytoma. Koçak E, Ballerini G, Zouhair A, Özşahin M. Turk J Haematol. 2010;27:57–61. - PubMed

Publication types

LinkOut - more resources