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Review
. 2022 Apr 5;14(4):e23864.
doi: 10.7759/cureus.23864. eCollection 2022 Apr.

Puberty Induction in Adolescent Males: Current Practice

Mohammed S Alenazi  1   2 , Ali M Alqahtani  2 , Mohammad M Ahmad  2 , Eyad M Almalki  3 , Angham AlMutair  4   5 , Mussa Almalki  2   6
Affiliations
Review

Puberty Induction in Adolescent Males: Current Practice

Mohammed S Alenazi et al. Cureus. .

Abstract

Puberty is a developmental stage characterized by the appearance of secondary sexual characteristics which leads to complete physical, psychosocial, and sexual maturation. The current practice of hormonal therapy to induce puberty in adolescent males is based on published consensus and expert opinion. Evidence-based guidelines on optimal timing and regimen in puberty induction in males are lacking, and this reflects some discrepancies in practice among endocrinologists. It is worth mentioning that the availability of various hormonal products in markets, their different routes of administration, and patients/parents' preference also have an impact on clinical decisions. This review outlines the current clinical approach to delayed puberty in boys with an emphasis on puberty induction.

Keywords: adolescent; and gnrh therapy.; boys; gonadotropins; hypogonadism; pubertal delay; testosterone.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Normal puberty physiology.
Figure 2
Figure 2. Diagnostic approach to a boy with suspected delayed puberty.
Figure 3
Figure 3. Suggested treatment approach for patients with delayed puberty due to HH (complete or stalled puberty).
Figure 4
Figure 4. Suggested treatment approach for patients with delayed puberty due to CDGP.
CDGP - Constitutional delay of growth and puberty
Figure 5
Figure 5. Hormonal replacement in hypergonadotropic hypogonadism (low testosterone, high LH and FSH) (e.g., Klinefelter syndrome 47 XXY mixed gonadal dysgenesis 46 X0, XX, congenital anorchia and testicular postradiotherapy).
See this image and copyright information in PMC

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