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Review
. 2022 Apr;10(7):421.
doi: 10.21037/atm-22-1016.

Research progress on cognitive impairment and the expression of serum inflammatory markers in patients with white matter hyperintensities: a narrative review

Shanshan Qiao  1 , Haitao Li  1 , Fang Guo  1 , Guilan Cai  1 , Yongbo Zhang  1
Affiliations
Review

Research progress on cognitive impairment and the expression of serum inflammatory markers in patients with white matter hyperintensities: a narrative review

Shanshan Qiao et al. Ann Transl Med. 2022 Apr.

Abstract

Background and objective: White matter hyperintensities (WMH) are magnetic resonance imaging manifestations of brain white matter lesions, which are common in the elderly. There is a correlation between WMH and cognitive impairment, but its imaging features lack heterogeneity, which makes early diagnosis difficult. Studies have found that cognitive impairment in patients with WMH is closely related to changes in the expression of serum inflammatory markers. This article reviews the correlation between WMH and cognitive function, as well as the correlation between cognitive impairment and serum inflammatory markers in patients with WMH.

Methods: We searched the China National Knowledge Infrastructure (CNKI), PubMed, Medline and EMBASE databases to identify studies on the correlation between cognitive impairment and serum inflammatory markers in patients with WMH published between the databases' dates of inception and December 2021.

Key content and findings: Serum inflammatory markers such as C-reactive protein (CRP), tumor necrosis factor α (TNF-α), plasma lipoprotein phospholipase A2 (Lp-PLA2) and interleukins (ILs) are closely related to cognitive impairment in patients with WMH.

Conclusions: CRP, TNF-α, ILs and others systemic inflammatory markers can be used to help diagnose and predict cognitive impairment in WMH patients. But more in-depth and comprehensive research is needed to determine the role of systemic inflammatory markers in diagnosing WMH cognitive impairment.

Keywords: White matter hyperintensity (WMH); cognitive impairment; inflammatory markers.

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Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://atm.amegroups.com/article/view/10.21037/atm-22-1016/coif). The authors have no conflicts of interest to declare.

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References

    1. Alber J, Alladi S, Bae HJ, et al. White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities. Alzheimers Dement (N Y) 2019;5:107-17. 10.1016/j.trci.2019.02.001 - DOI - PMC - PubMed
    1. Ma Y, Song A, Viswanathan A, et al. Blood Pressure Variability and Cerebral Small Vessel Disease: A Systematic Review and Meta-Analysis of Population-Based Cohorts. Stroke 2020;51:82-9. 10.1161/STROKEAHA.119.026739 - DOI - PMC - PubMed
    1. Xu Z, Li F, Wang B, et al. New Insights in Addressing Cerebral Small Vessel Disease: Association With the Deep Medullary Veins. Front Aging Neurosci 2020;12:597799. 10.3389/fnagi.2020.597799 - DOI - PMC - PubMed
    1. Yu C, Lu W, Qiu J, et al. Alterations of the Whole Cerebral Blood Flow in Patients With Different Total Cerebral Small Vessel Disease Burden. Front Aging Neurosci 2020;12:175. 10.3389/fnagi.2020.00175 - DOI - PMC - PubMed
    1. Ghaznawi R, Geerlings MI, Jaarsma-Coes MG, et al. The association between lacunes and white matter hyperintensity features on MRI: The SMART-MR study. J Cereb Blood Flow Metab 2019;39:2486-96. 10.1177/0271678X18800463 - DOI - PMC - PubMed