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Case Reports
. 2022 Mar 21;9(5):ofac136.
doi: 10.1093/ofid/ofac136. eCollection 2022 May.

A Case of Burkholderia pseudomallei Mycotic Aneurysm Linked to Exposure in the Caribbean via Whole-Genome Sequencing

Lisa J Speiser  1 , Sabirah Kasule  1 , Carina M Hall  2 , Jason W Sahl  2 , David M Wagner  2 , Chris Saling  1 , Amy Kole  1 , Andrew J Meltzer  1 , Victor Davila  1 , Robert Orenstein  1 , Thomas Grys  1 , Erin Graf  1
Affiliations
Case Reports

A Case of Burkholderia pseudomallei Mycotic Aneurysm Linked to Exposure in the Caribbean via Whole-Genome Sequencing

Lisa J Speiser et al. Open Forum Infect Dis. .

Abstract

Melioidosis, an infection caused by Burkholderia pseudomallei, has a very high risk of mortality when treated, with an even higher risk of fatality if undiagnosed or not treated appropriately. It is endemic to Asia, Australia, South America, and the Caribbean; however, the number of melioidosis cases reported in the United States has been increasing. Therefore, physicians should be aware of this clinical entity and its possible presentations. Mycotic aneurysms due to B. pseudomallei are extremely rare, accounting for ~1%-2% of cases. Here we describe a rare case of melioidosis presenting as a mycotic aneurysm in the United States, highlight the potential for diagnostic challenges and epidemiologic concerns, and provide a review of mycotic aneurysm cases due to B. pseudomallei published to date.

Keywords: Burkholderia; anneurysm; melioidosis; mycotic; pseudomallei.

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Figures

Figure 1.
Figure 1.
Macroscopic and microscopic morphology of B. pseudomallei.
Figure 2.
Figure 2.
Phylogenetic analysis.
See this image and copyright information in PMC

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