Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2022 Mar 21;9(5):ofac136.
doi: 10.1093/ofid/ofac136. eCollection 2022 May.

A Case of Burkholderia pseudomallei Mycotic Aneurysm Linked to Exposure in the Caribbean via Whole-Genome Sequencing

Lisa J Speiser  1 , Sabirah Kasule  1 , Carina M Hall  2 , Jason W Sahl  2 , David M Wagner  2 , Chris Saling  1 , Amy Kole  1 , Andrew J Meltzer  1 , Victor Davila  1 , Robert Orenstein  1 , Thomas Grys  1 , Erin Graf  1
Affiliations
Case Reports

A Case of Burkholderia pseudomallei Mycotic Aneurysm Linked to Exposure in the Caribbean via Whole-Genome Sequencing

Lisa J Speiser et al. Open Forum Infect Dis. .

Abstract

Melioidosis, an infection caused by Burkholderia pseudomallei, has a very high risk of mortality when treated, with an even higher risk of fatality if undiagnosed or not treated appropriately. It is endemic to Asia, Australia, South America, and the Caribbean; however, the number of melioidosis cases reported in the United States has been increasing. Therefore, physicians should be aware of this clinical entity and its possible presentations. Mycotic aneurysms due to B. pseudomallei are extremely rare, accounting for ~1%-2% of cases. Here we describe a rare case of melioidosis presenting as a mycotic aneurysm in the United States, highlight the potential for diagnostic challenges and epidemiologic concerns, and provide a review of mycotic aneurysm cases due to B. pseudomallei published to date.

Keywords: Burkholderia; anneurysm; melioidosis; mycotic; pseudomallei.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Macroscopic and microscopic morphology of B. pseudomallei.
Figure 2.
Figure 2.
Phylogenetic analysis.
See this image and copyright information in PMC

References

    1. Dance DA. Ecology of Burkholderia pseudomallei and the interactions between environmental Burkholderia spp. and human-animal hosts. Acta Trop 2000; 74:159–68. - PubMed
    1. White NJ. Melioidosis. Lancet 2003; 361:1715–22. - PubMed
    1. Cheng AC, Currie BJ.. Melioidosis: epidemiology, pathophysiology, and management. Clin Microbiol Rev 2005; 18:383–416. - PMC - PubMed
    1. Centers for Disease Control and Prevention. Statement on melioidosis cases. Available at: https://www.cdc.gov/media/releases/2021/s0909-melioidosis.html. Accessed 29 September 2021.
    1. Centers for Disease Control and Prevention. 2021 multistate outbreak of melioidosis. Available at: https://www.cdc.gov/melioidosis/outbreak/2021/index.html. Accessed 1 February 2022.

Publication types