Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Apr 15;9(5):ofac173.
doi: 10.1093/ofid/ofac173. eCollection 2022 May.

Follow-up Blood Culture Practices for Gram-Negative Bloodstream Infections in Immunocompromised Hosts at a Large Academic Medical Center

Lauren Groft Buzzalino  1 , James Mease  2 , Ciera L Bernhardi  3 , Jacqueline T Bork  4 , J Kristie Johnson  4 , Kimberly C Claeys  5
Affiliations

Follow-up Blood Culture Practices for Gram-Negative Bloodstream Infections in Immunocompromised Hosts at a Large Academic Medical Center

Lauren Groft Buzzalino et al. Open Forum Infect Dis. .

Abstract

The role of follow-up blood cultures (FUBCs) in gram-negative bloodstream infections to improve clinical outcomes remains controversial, especially among immunocompromised patients. Among 139 patients, FUBCs were common (117, 84.2%); however, positive FUBCs were rare (3, 2.6%). Only presence of fever was associated with a positive FUBC.

Keywords: bloodstream infection; gram-negative; immunocompromise; oncology; transplant.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Microbiologic distribution of index blood cultures. aEnterobacter hormaechei, Citrobacter spp., Klebsiella variicola, Morganella morganii, Pantoea spp., Pluralibacter (Enterobacter) gergoviae, Raoultella (Klebsiella) planticola, Stenotrophomonas maltophilia.
See this image and copyright information in PMC

References

    1. Liu C, Bayer A, Cosgrove SE, et al. Clinical practice guidelines by the Infectious Diseases Society of America for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children: executive summary. Clin Infect Dis 2011; 52:285–92. - PubMed
    1. Pappas PG, Kauffman CA, Andes DR, et al. Clinical practice guideline for the management of candidiasis: 2016 update by the Infectious Diseases Society of America. Clin Infect Dis 2016; 62:e1–50. doi: 10.1093/cid/civ933. Epub 2015 Dec 16. PMID: 26679628; PMCID: PMC4725385. - DOI - PMC - PubMed
    1. Harris JA, Cobbs CG.. Persistent gram-negative bacteremia: observations in twenty patients. Am J Surg 1973; 125:705–17. - PubMed
    1. Maskarinec SA, Park LP, Ruffin F, et al. Positive follow-up blood cultures identify high mortality risk among patients with gram-negative bacteraemia. Clin Microbiol Infect 2020; 26:904–10. - PMC - PubMed
    1. Giannella M, Pascale R, Pancaldi L, et al. Follow-up blood cultures are associated with improved outcome of patients with gram-negative bloodstream infections: retrospective observational cohort study. Clin Microbiol Infect 2020; 26:897–903. - PubMed