Insights into the release mechanisms of antioxidants from nanoemulsion droplets

Abstract

The therapeutic effects of antioxidant-loaded nanoemulsion can be often optimized by controlling the release rate in human body. Release kinetic models can be used to predict the release profile of antioxidant compounds and allow identification of key parameters that affect the release rate. It is known that one of the critical aspects in establishing a reliable release kinetic model is to understand the underlying release mechanisms. Presently, the underlying release mechanisms of antioxidants from nanoemulsion droplets are not yet fully understood. In this context, this review scrutinized the current formulation strategies to encapsulate antioxidant compounds and provide an outlook into the future of this research area by elucidating possible release mechanisms of antioxidant compounds from nanoemulsion system.

Keywords: Antioxidant; Controlled release; Nanoemulsion; Release mechanism.

Fig. 1

Examples of nutraceutical-based delivery system

Fig. 2

Schematic presentation of diffusion-controlled release of antioxidant compounds from nanoemulsion system

Fig. 3

Schematic presentation of polymer chain relaxation where the macromolecules change from the glassy state to the rubbery state

Fig. 4

Schematic presentation of an anionic polymer coating the antioxidant-loaded nanoemulsion, exhibiting in the acidic gastric condition (left) and basic small intestine condition (right)