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. 2022 Oct;77(10):3124-3162.
doi: 10.1111/all.15364. Epub 2022 May 22.

Updated threshold dose-distribution data for sesame

Paul J Turner  1 , Magdalena Gretzinger  1 , Nandinee Patel  1 , Helen A Brough  2   3 , R Sharon Chinthrajah  4 , Motohiro Ebisawa  5 , Arnon Elizur  6   7 , Jennifer J Koplin  8   9 , Rachel L Peters  8   9 , Natasha Purington  10 , Anna Nowak-Wegrzyn  11   12 , Sarah Saf  13   14 , Hugh A Sampson  13 , Joost Westerhout  15 , W Marty Blom  15 , Joseph L Baumert  16 , Geert F Houben  15 , Benjamin C Remington  16
Affiliations

Updated threshold dose-distribution data for sesame

Paul J Turner et al. Allergy. 2022 Oct.
No abstract available

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Conflict of interest statement

P.J. Turner reports personal fees from Aimmune Therapeutics, Allergenis, Aquestive, and UK Food Standards Agency pe; grants from NIHR/Imperial BRC, UK Medical Research Council, UK Food Standards Agency, Jon Moulton Charity Trust, outside the submitted work. H. Brough declares speaker fees from DBV Technologies and Sanofi, and research grants from NIH (NAIAD), DBV Technologies and Aimmune Therapeutics. S. Chinthrajah reports grants from NIAID, CoFAR, Aimmune Therapeutics, DBV Technologies, Astellas, Regeneron, FARE, Stanford Maternal and Child Health Research Institute (MCHRI); other support from Alladapt Therapeutics, Novartis, Genentech, Sanofi, Allergenis, Nutricia, outside the submitted work. M. Ebisawa reports personal fees from DBV Technologies, Mylan, ARS Pharmaceuticals, outside the submitted work. J. Koplin and R. Peters receive research support from the National Health and Medical Research Council of Australia. A. Nowak‐Wegrzyn reports royalty payments from UpToDate; personal fees from the American College of Allergy, Asthma, and Immunology as Deputy Editor of the Annals of Allergy, Asthma, and Immunology; consulting fees from Nestle, Nutricia, Novartis, and Aimmune outside of the submitted work. H. Sampson reports grants from Immune Tolerance Network, NIAID/NIH, personal fees and other support from N‐Fold Therapeutics, DBV Technologies, and personal fees from Siolta Therapeutics, outside the submitted work. J Westerhout, WM Blom and GF Houben report financial support from Dutch Governmental TNO Research Cooperation Funds, Netherlands, and the Food Allergy Research and Resource Program (FARRP) of the University of Nebraska, USA. BC Remington reports grants from FARRP, grants and personal fees from DBV Technologies, and travel support from ILSI Europe, outside the submitted work. The other authors declare no competing interests.

Figures

FIGURE 1
FIGURE 1
Eliciting dose curves from the model averaged population threshold dose‐distributions for sesame, based on (A) discrete and (B) cumulative dose datasets. Doses are expressed in mg sesame seed protein, and are compared to equivalent data reported by Houben et al. used to inform VITAL 3.0 reference doses
See this image and copyright information in PMC

Comment in

References

    1. Remington BC, Westerhout J, Meima MY, et al. Updated population minimal eliciting dose distributions for use in risk assessment of 14 priority food allergens. Food Chem Toxicol. 2020;139:111259. - PMC - PubMed
    1. Remington BC, Westerhout J, Dubois AEJ, et al. Suitability of low‐dose, open food challenge data to supplement double‐blind, placebo‐controlled data in generation of food allergen threshold dose distributions. Clin Exp Allergy. 2021;51(1):151‐154. - PubMed
    1. Klein Entink RH, Remington BC, Blom WM, et al. Food allergy population thresholds: an evaluation of the number of oral food challenges and dosing schemes on the accuracy of threshold dose distribution modeling. Food Chem Toxicol. 2014;70:134‐143. - PubMed
    1. Ad hoc joint FAO/WHO expert consultation on risk assessment of food allergens part 1: summary and conclusions of the review and validation of codex priority allergen list through risk assessment. Issued on 10 May 2021. Available at fao.org/3/cb4653en/cb4653en.pdf (accessed 20 March 2022).
    1. Houben GF, Baumert JL, Blom WM, et al. Full range of population eliciting dose values for 14 priority allergenic foods and recommendations for use in risk characterization. Food Chem Toxicol. 2020;146:111831. - PMC - PubMed

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