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Observational Study
. 2022 Aug;116(2):266-275.
doi: 10.1007/s12185-022-03351-7. Epub 2022 May 9.

Nutritional status and quality of life in adults undergoing allogeneic hematopoietic stem cell transplantation

Marco Cioce  1 , Stefano Botti  2 , Franziska Michaela Lohmeyer  3 , Eugenio Galli  4 , Marinella Magini  5 , Alessandra Giraldi  5 , Paola Garau  1 , Danilo Celli  6 , Maurizio Zega  1 , Simona Sica  7 , Andrea Bacigalupo  4 , Valerio De Stefano  4 , Ivan Borrelli  8 , Umberto Moscato  9
Affiliations
Observational Study

Nutritional status and quality of life in adults undergoing allogeneic hematopoietic stem cell transplantation

Marco Cioce et al. Int J Hematol. 2022 Aug.

Abstract

Although the effects of malnutrition on morbidity and mortality in adult patients undergoing allogeneic hematopoietic stem cell transplantation are clear, the relationship with quality of life (QOL) is less clear. The purpose of this study was to assess the relationship between malnutrition and QOL. A prospective observational study was conducted in 36 adult patients undergoing allogeneic hematopoietic stem cell transplantation. Adapted criteria of the Global Leadership Initiative on malnutrition have been used for the diagnosis of malnutrition in clinical settings. A cancer linear analog scale was used to assess QOL. Overall QOL at 14 days after allogeneic hematopoietic stem cell transplantation was 37.1 (95% CI 2.9-45.39) in patients without severe malnutrition, versus 16.0 (95% CI - 6.6 to 38.6) in patients with severe malnutrition (p = 0.05). At discharge, it was 48.0 (95% CI 38.4-57.6) versus 34.0 (95% CI 4.1-63.9) (p = 0.27). The results of our study suggest that patients with severe malnutrition at discharge tend to have worse QOL. A larger cohort of patients is required to confirm this hypothesis.

Keywords: Allogeneic hematopoietic stem cell transplantation; Malnutrition; Nutritional status; Nutritional support; Quality of life.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
Relationship between complications and nutritional support during allo-HSCT
Fig. 2
Fig. 2
a Energy level and severe malnutrition at discharge. b Daily life activities and severe malnutrition at discharge. c Quality of life and severe malnutrition at discharge
Fig. 3
Fig. 3
Quality of life and severe malnutrition at + 14 day after allo-HSCT
See this image and copyright information in PMC

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