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Review
. 2022 Jul;77(1):237-242.
doi: 10.1016/j.jhep.2022.05.001. Epub 2022 May 6.

The recent outbreak of acute severe hepatitis in children of unknown origin - what is known so far

Marcus Maximilian Mücke  1 , Stefan Zeuzem  2
Affiliations
Review

The recent outbreak of acute severe hepatitis in children of unknown origin - what is known so far

Marcus Maximilian Mücke et al. J Hepatol. 2022 Jul.

Abstract

At the beginning of April 2022, 10 cases of severe acute hepatitis of unknown origin in children <10 years of age were reported across central Scotland. Since then, case numbers have increased rapidly, with 191 probable cases identified across Europe, the United States of America, Israel and Japan. Until now, 17 children required liver transplantation and 1 died. Accordingly, the Centers for Disease Control and Prevention and the European Centre for Diseases Prevention and Control have both issued a warning on a hepatitis of unknown origin in children. This review focuses on the available information concerning this recent outbreak and introduces some of the potential explanations for its development.

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Conflict of interest statement

Conflict of interest The authors declare no conflicts of interest that pertain to this work.

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