Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 May 9;12(5):e054193.
doi: 10.1136/bmjopen-2021-054193.

Changes in perioperative red cell transfusion practice over time in patients undergoing surgery for upper gastrointestinal and liver cancer: a retrospective cohort study at a single tertiary centre

Mei Yi Yee  1 , Ewen Harrison  2 , Riinu Pius  2 , Michael Gillies  3
Affiliations

Changes in perioperative red cell transfusion practice over time in patients undergoing surgery for upper gastrointestinal and liver cancer: a retrospective cohort study at a single tertiary centre

Mei Yi Yee et al. BMJ Open. .

Abstract

Objectives: Optimum transfusion trigger for adults undergoing cancer surgery is uncertain. Published guidelines recommend restrictive transfusion strategies in hospitalised adults. We aimed to measure the red cell transfusion rate and haemoglobin trigger in patients undergoing cancer surgery and how closely practice reflected published guidelines.

Design: Retrospective cohort study.

Setting: Single tertiary centre.

Participants: Adult patients undergoing surgery for upper gastrointestinal or liver malignancy.

Exposure: Postguideline change (2015-2017) versus preguideline change (2011-2012).

Outcome measures: Primary: transfusion rate, secondary: transfusion trigger. Multivariable logistic regression was used to assess factors and adjust for confounders affecting our outcome measures.

Results: 1578 surgical records were identified for 1520 patients. 946/1530 (62%) patients had preoperative anaemia. The transfusion rate decreased from 23% in 2011-2012 to 14% in 2015-2017. This change remained significant after adjusting for other variables associated with transfusion rates. Mean pretransfusion haemoglobin in those who were transfused was 78±13 g/L in 2011-2012 and 80±15 g/L in 2015-2017. This change in haemoglobin transfusion triggers was not significant.

Conclusion: Transfusion rate has decreased over the study period in patients undergoing surgery for malignancy and is consistent with a restrictive transfusion strategy.

Keywords: anaemia; cancer; health services research; surgery; transfusion.

PubMed Disclaimer

Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Flowchart illustrating surgical records identification and eligibility. ORSOS, Operating Room Schedule and Office System.
Figure 2
Figure 2
OR predicting factors associated with transfusion. Outcome was transfusion, primary exposure year of surgery. Multivariable model is adjusted for age, gender, type of procedure, ASA and urgency. ASA, American Society of Anaesthesiologists.
See this image and copyright information in PMC

References

    1. World Health Organization . Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity. World health organization 2011.
    1. Dicato M, Plawny L, Diederich M. Anemia in cancer. Ann Oncol 2010;21 Suppl 7:vii167–72. 10.1093/annonc/mdq284 - DOI - PubMed
    1. Schrijvers D. Management of anemia in cancer patients: transfusions. Oncologist 2011;16 (Suppl 3):12–18. 10.1634/theoncologist.2011-S3-12 - DOI - PubMed
    1. Muñoz M, Gómez-Ramírez S, Campos A, et al. . Pre-Operative anaemia: prevalence, consequences and approaches to management. Blood Transfus 2015;13:370. 10.2450/2015.0014-15 - DOI - PMC - PubMed
    1. Karkouti K, Wijeysundera DN, Beattie WS, et al. . Risk associated with preoperative anemia in cardiac surgery: a multicenter cohort study. Circulation 2008;117:478–84. 10.1161/CIRCULATIONAHA.107.718353 - DOI - PubMed