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. 2022 Jul;33(7):447-450.
doi: 10.1016/j.tem.2022.04.006. Epub 2022 May 7.

Metabolic oscillations during cell-cycle progression

Philippe Icard  1 , Luca Simula  2
Affiliations

Metabolic oscillations during cell-cycle progression

Philippe Icard et al. Trends Endocrinol Metab. 2022 Jul.

Abstract

We discuss how metabolism changes during different phases of the cell cycle to sustain biosynthesis and replication in normal and cancer cells. We also highlight how several master regulators of cell cycle, such as cyclin-cyclin-dependent kinases (cyc-CDK complexes) and E3 proteasome ligases, modulate key metabolic enzymes to support cell-cycle progression.

Keywords: Warburg effect; cancer; cell cycle; cell metabolism.

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