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Review
. 2022 May 9;12(1):18.
doi: 10.1007/s13659-022-00339-y.

Antiaging agents: safe interventions to slow aging and healthy life span extension

Ji-Kai Liu  1
Affiliations
Review

Antiaging agents: safe interventions to slow aging and healthy life span extension

Ji-Kai Liu. Nat Prod Bioprospect. .

Abstract

Human longevity has increased dramatically during the past century. More than 20% of the 9 billion population of the world will exceed the age of 60 in 2050. Since the last three decades, some interventions and many preclinical studies have been found to show slowing aging and increasing the healthy lifespan of organisms from yeast, flies, rodents to nonhuman primates. The interventions are classified into two groups: lifestyle modifications and pharmacological/genetic manipulations. Some genetic pathways have been characterized to have a specific role in controlling aging and lifespan. Thus, all genes in the pathways are potential antiaging targets. Currently, many antiaging compounds target the calorie-restriction mimetic, autophagy induction, and putative enhancement of cell regeneration, epigenetic modulation of gene activity such as inhibition of histone deacetylases and DNA methyltransferases, are under development. It appears evident that the exploration of new targets for these antiaging agents based on biogerontological research provides an incredible opportunity for the healthcare and pharmaceutical industries. The present review focus on the properties of slow aging and healthy life span extension of natural products from various biological resources, endogenous substances, drugs, and synthetic compounds, as well as the mechanisms of targets for antiaging evaluation. These bioactive compounds that could benefit healthy aging and the potential role of life span extension are discussed.

Keywords: Antiaging agents; Antiaging targets; Endogenous substances; Healthy lifespan extension; Longevity; Natural products.

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Scheme 1
Scheme 1
The structures of natural products as antiaging agents
Scheme 2
Scheme 2
The structures of natural products as antiaging agents
Scheme 3
Scheme 3
The structures of natural products as antiaging agents
Scheme 4
Scheme 4
The structures of endogenous substances with the activity of life span extension
Scheme 5
Scheme 5
The structures of drugs and synthetic compounds with antiaging effects
Fig. 1
Fig. 1
Proposed algorithm to screen antiaging agents
Fig. 2
Fig. 2
Overview of macroautophagy [201]
Scheme 6
Scheme 6
The structures of caloric restriction mimics
Scheme 7
Scheme 7
The structures of natural products with antiaging effects
See this image and copyright information in PMC

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