Review
Control of aldosterone secretion by pituitary hormones
- PMID: 3553489
Item in Clipboard
Review
Control of aldosterone secretion by pituitary hormones
J Hypertens Suppl.
1986 Dec.
Abstract
Pro-gamma-melanotropins (pro-gamma-MSH) are implicated in the control of aldosterone secretion by the normal adrenal cortex and in idiopathic hyperaldosteronism. In contrast with other melanotropins (alpha- and beta-MSH), the pro-gamma-MSH increase aldosterone secretion by normal adrenals only in the presence of adrenocorticotrophic hormone (ACTH). However, in aldosteronoma cells this stimulatory effect of the pro-gamma-MSH is not ACTH-dependent. The mechanism of pro-gamma-MSH action on aldosterone biosynthesis may involve activation of cholesteryl ester hydrolase in zona glomerulosa, resulting in an increased provision of cholesterol for steroidogenesis.
Similar articles
-
Plasma immunoreactive gamma melanotropin in patients with idiopathic hyperaldosteronism, aldosterone-producing adenomas, and essential hypertension.J Clin Invest. 1985 Jul;76(1):163-9. doi: 10.1172/JCI111941. J Clin Invest. 1985. PMID: 4019776 Free PMC article.
-
Response of human aldosteronoma cells in culture to the N-terminal glycopeptide of pro-opiomelanocortin and gamma 3-MSH.Horm Metab Res. 1983 Apr;15(4):181-4. doi: 10.1055/s-2007-1018663. Horm Metab Res. 1983. PMID: 6862354
-
Aldosterone and corticosterone stimulation by ACTH in isolated rat adrenal glomerulosa cells: interaction with vasopressin.J Physiol (Paris). 1982;78(3):317-21. J Physiol (Paris). 1982. PMID: 6300381
-
Pituitary proopiomelanocortin-derived peptides and hypothalamus-pituitary-interrenal axis activity in gilthead sea bream (Sparus aurata) during prolonged crowding stress: differential regulation of adrenocorticotropin hormone and alpha-melanocyte-stimulating hormone release by corticotropin-releasing hormone and thyrotropin-releasing hormone.Gen Comp Endocrinol. 2000 Aug;119(2):152-63. doi: 10.1006/gcen.2000.7508. Gen Comp Endocrinol. 2000. PMID: 10936035
-
A possible role for intermediate lobe peptides in the pathogenesis of idiopathic aldosteronism.Trans Am Clin Climatol Assoc. 1984;95:26-33. Trans Am Clin Climatol Assoc. 1984. PMID: 6089399 Free PMC article. No abstract available.
Cited by
-
Effect of verapamil on aldosterone secretion in primary aldosteronism.J Endocrinol Invest. 1987 Oct;10(5):491-4. doi: 10.1007/BF03348177. J Endocrinol Invest. 1987. PMID: 3429788
-
Systems-level engineering of nonfermentative metabolism in yeast.Genetics. 2009 Sep;183(1):385-97. doi: 10.1534/genetics.109.105254. Epub 2009 Jun 29. Genetics. 2009. PMID: 19564482 Free PMC article.