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. 2022 Mar-Apr;12(2):719-720.
doi: 10.1016/j.jceh.2021.07.006. Epub 2021 Jul 16.

Giant Cell Hepatitis in Copper Toxicosis

Mukul Vij  1 , Srinivas Sankaranarayanan  2 , Valavanur Subramanian Sankaranarayanan  2 , Rakesh Manoharan  3 , Sivanandam Sundaram  4
Affiliations

Giant Cell Hepatitis in Copper Toxicosis

Mukul Vij et al. J Clin Exp Hepatol. 2022 Mar-Apr.

Abstract

Cholestatic jaundice in new born and infants results from biliary obstruction or hepatocellular dysfunction. Biliary atresia (BA) and Idiopathic neonatal hepatitis comprises the major aetiology. Cholestasis due to toxins is rare in infants. Indian childhood cirrhosis (ICC) and ICC like diseases have been described in infants. Herein, authors are describing a case of infantile cholestasis presenting at 4 months of age who was diagnosed to have copper related hepatotoxicosis on liver biopsy. Copper tumblers were used for preparation of formula milk that likely was the source of exogenous copper and the child improved well after removing the source of exogenous copper.

Keywords: Copper toxicity; Giant cell hepatitis; Infantile cholestasis; Scarring.

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Figures

Figure 1
Figure 1
1st liver biopsy with lobular disarray and multinucleate giant cells (H&E, A). Higher power demonstrating fibrosis, giant cells, and inflammation (H&E, B). Marked fibrosis in the liver tissue (MT, C). Stainable copper deposits (Rhodanine, D) 2nd liver biopsy with maintained lobular architecture and marked reduction is fibrosis (H&E, E).
See this image and copyright information in PMC

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