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. 2022 Jul;56(4):199-204.
doi: 10.4132/jptm.2022.03.19. Epub 2022 May 11.

Correlation between myoferlin expression and lymph node metastasis in papillary thyroid carcinoma

Ji Min Na  1 , Dong Chul Kim  1   2   3 , Dae Hyun Song  2   3   4 , Hyo Jung An  4 , Hyun Min Koh  5 , Jeong-Hee Lee  1   2   3 , Jong Sil Lee  1   2   3 , Jung Wook Yang  1   2   3 , Min Hye Kim  1
Affiliations

Correlation between myoferlin expression and lymph node metastasis in papillary thyroid carcinoma

Ji Min Na et al. J Pathol Transl Med. 2022 Jul.

Abstract

Background: Myoferlin is a multifunctional protein expressed in various normal and cancer cells, with novel oncogenic roles being newly discovered. Recently, correlations have been found between myoferlin expression and unfavorable prognosis in various carcinomas. This study investigated the prognostic role of myoferlin expression in papillary thyroid carcinoma (PTC), specifically that associated with nodal metastasis.

Methods: We collected clinicopathological data and PTC tissues from 116 patients who had been admitted to Gyeongsang National University Hospital in 2010. Immunohistochemical analysis was performed on surgical specimen-derived tissue microarray blocks. Myoferlin expression was graded, and the relationship between expression level and pathological features of tumors based on the American Joint Committee on Cancer staging system was evaluated.

Results: Of the 116 patient samples, 100 cases exhibited positive myoferlin expression. Higher grade of myoferlin expression was correlated with lower T category group (p = .010). Presence of lymph node metastasis was determined to be significantly correlated with low-grade myoferlin expression (p = .019), with no significant difference between pN1a and pN1b tumors.

Conclusions: Our study revealed an adverse correlation between myoferlin expression and pathological features of PTC, evidence of the potential prognostic role of myoferlin in PTC lymph node metastasis.

Keywords: Lymph node metastasis; Myoferlin; Papillary thyroid carcinoma; Tumor staging.

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Conflict of interest statement

Conflicts of Interest

The authors declare that they have no potential conflicts of interest.

Figures

Fig. 1
Fig. 1
(A) Myoferlin expression observed in the cytoplasm and membrane of normal thyroid follicular cells. (B–E) Myoferlin expression observed in papillary thyroid carcinoma. Negative (B), weak (+1) (C), moderate (+2) (D), and strong (+3) (E) myoferlin expression in tumor cells.
See this image and copyright information in PMC

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