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Review
. 2022 Jun;26(11):3120-3132.
doi: 10.1111/jcmm.17355. Epub 2022 May 10.

Putative therapeutic impacts of cardiac CTRP9 in ischaemia/reperfusion injury

Seyyed-Reza Sadat-Ebrahimi  1 , Hassan Amini  2   3 , Reza Rahbarghazi  3   4 , Paria Habibollahi  5 , Shahrouz Ghaderi  6 , Hadi Rajabi  7 , Aysa Rezabakhsh  1   8
Affiliations
Review

Putative therapeutic impacts of cardiac CTRP9 in ischaemia/reperfusion injury

Seyyed-Reza Sadat-Ebrahimi et al. J Cell Mol Med. 2022 Jun.

Abstract

Recently, cytokines belonging to C1q/tumour necrosis factor-related proteins (CTRPs) superfamily have attracted increasing attention due to multiple metabolic functions and desirable anti-inflammatory effects. These various molecular effectors exhibit key roles upon the onset of cardiovascular diseases, making them novel adipo/cardiokines. This review article aimed to highlight recent findings correlated with therapeutic effects and additional mechanisms specific to the CTRP9, particularly in cardiac ischaemia/reperfusion injury (IRI). Besides, the network of the CTPR9 signalling pathway and its possible relationship with IRI were discussed. Together, the discovery of all involved underlying mechanisms could shed light to alleviate the pathological sequelae after the occurrence of IRI.

Keywords: CTRP9; ischaemia/reperfusion injury; signalling pathways; therapeutic target.

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Conflict of interest statement

None declared.

Figures

FIGURE 1
FIGURE 1
Schematic illustration of IRI pathophysiology in the cardiomyocytes during ischaemic and reperfusion states
FIGURE 2
FIGURE 2
Similar structural characteristics of adiponectin (APN) and CTRP9 molecules
FIGURE 3
FIGURE 3
Multiple therapeutic impacts of CTRP9 under IRI. (A) anti‐apoptotic signalling pathway of CTRP9 mediated by AdipoR‐1‐dependent and autocrine manners. AMPK and S1P are two critical regulators of the CTRP9‐related signalling pathway to exert cardioprotective and anti‐apoptotic effects. (B) CTRP9 also represents an autophagy modulatory effect under different stress conditions, for example short and long‐term IRI. (C) anti‐inflammatory effect of CTRP9 by targeting pro‐inflammatory cytokines, NADPH oxidase subtypes and immune cells
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References

    1. Roger VL, Go AS, Lloyd‐Jones DM, et al. Heart disease and stroke statistics–2011 update: a report from the American Heart Association. Circulation. 2011;123(4):e18‐e209. - PMC - PubMed
    1. Bainey KR, Armstrong PW. Clinical perspectives on reperfusion injury in acute myocardial infarction. Am Heart J. 2014;167(5):637‐645. - PubMed
    1. Gu H‐F, Li H‐Z, Tang Y‐L, Tang X‐Q, Zheng X‐L, Liao D‐F. Nicotinate‐curcumin impedes foam cell formation from THP‐1 cells through restoring autophagy flux. PLoS One. 2016;11(4):e0154820. - PMC - PubMed
    1. Ong S‐B, Katwadi K, Kwek X‐Y, et al. Non‐coding RNAs as therapeutic targets for preventing myocardial ischemia‐reperfusion injury. Exp Opin Ther Targets. 2018;22(3):247‐261. - PubMed
    1. Miller MA, Zachary JF. Mechanisms and morphology of cellular injury, adaptation, and death. Pathol Basis Vet Dis. 2017:2‐43.e19.