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. 2022 Nov 30;18(5):2055422.
doi: 10.1080/21645515.2022.2055422. Epub 2022 May 10.

Vaccine uptake and barriers to vaccination among at-risk adult populations in the US

Irina Kolobova  1 , Mawuli Kwame Nyaku  1 , Anna Karakusevic  2 , Daisy Bridge  2 , Iain Fotheringham  2 , Megan O'Brien  1
Affiliations

Vaccine uptake and barriers to vaccination among at-risk adult populations in the US

Irina Kolobova et al. Hum Vaccin Immunother. .

Abstract

To reduce morbidity and mortality associated with vaccine-preventable diseases (VPD), it is imperative that vaccination programs are implemented and prioritized throughout all stages of life across all populations. This study aimed to determine vaccine uptake and barriers to vaccination against VPDs among at-risk adult populations in the United States. We conducted a systematic literature review for articles published between January 2010 and June 2020 and identified 153 publications. The review identified 17 at-risk populations. Vaccine uptake was suboptimal among many populations, with factors including age, gender, and disease severity, associated with uptake. This review identified several barriers that impact vaccine uptake among at-risk populations, with concerns over safety, vaccine costs, lack of insurance, and lack of provider recommendation commonly reported across populations. Embracing a national life-course immunization framework that integrates developing policies, guidelines, and education would be a step to addressing these barriers.

Keywords: Vaccine-preventable diseases; at-risk population; barriers; life-course immunization; population health; public health; vaccine uptake rate.

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Conflict of interest statement

IK, MKN and MOB are employees of Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA and may own stocks and/or stock options in Merck & Co., Inc., Kenilworth, NJ, USA. AK, DB, and IF are employees of Adelphi Values PROVE™. Adelphi Values PROVE™ was compensated by Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA for the conduct of the study and development of the manuscript.

Figures

Figure 1.
Figure 1.
PRISMA diagram.
Figure 2.
Figure 2.
Influenza vaccine uptake among HCWs, by year.
Figure 3.
Figure 3.
Vaccine uptake among individuals with chronic liver disease, by year.
Figure 4.
Figure 4.
Influenza vaccine uptake among pregnant women, by year.,,,,*
Figure 5.
Figure 5.
Tdap vaccine uptake among pregnant women, by year.*
See this image and copyright information in PMC

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