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. 2022 Jun;15(3):e003592.
doi: 10.1161/CIRCGEN.121.003592. Epub 2022 May 10.

Integrative Analysis of Circulating Metabolite Levels That Correlate With Physical Activity and Cardiorespiratory Fitness

Matthew Nayor  1 , Ariel Chernofsky  2 , Patricia E Miller  2 , Nicole L Spartano  3 , Venkatesh L Murthy  4   5 , Rajeev Malhotra  6 , Nicholas E Houstis  7 , Joanne M Murabito  8   9 , Clary B Clish  10 , Martin G Larson  2   9 , Ramachandran S Vasan  9   11 , Ravi V Shah #  2   7   12 , Gregory D Lewis #  7   6   13
Affiliations

Integrative Analysis of Circulating Metabolite Levels That Correlate With Physical Activity and Cardiorespiratory Fitness

Matthew Nayor et al. Circ Genom Precis Med. 2022 Jun.
No abstract available

Keywords: accelerometry; cardiorespiratory fitness; exercise; exercise test; metabolomics; risk.

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Figures

Figure 1
Figure 1
Panel (A) includes a schematic of the study design. Panel (B) includes a Venn diagram illustrating the overlap of statistically significant (at FDR 5%) associations of resting metabolites with MVPA, steps/day, and SED (N=1062; linear models relating metabolite [dependent variable] to PA measure with adjustment for age, sex, location, season, and device wear time). Metabolite levels were log-transformed and rank-normalized (resulting in mean=0 and SD=1) for analysis. In Panel (C), the regression coefficients from individual associations of metabolites and MVPA, steps/day, and SED are shown for all metabolites associated with ≥2 PA measures, in a Heatmap format. The “*” indicates associations that are statistically significant (at FDR 5%). Panel (D) shows a Venn diagram displaying statistically significant associations (at FDR 5%) of metabolites with MVPA, associations of resting metabolites with peak VO2 (N=471, from prior report; linear models relating peak VO2 [dependent variable] to metabolite with adjustment for age and sex), and change in metabolite level from rest to peak exercise (N=411, from prior report; the log2 fold change in metabolite levels were assessed using 2-tailed t-tests). Panel (E), metabolites were plotted according to their association with MVPA (X-axis), association with peak VO2 (Y-axis) and their exercise-induced change (circle). The circle size reflects the magnitude of change from rest to peak exercise (expressed as the absolute value of the mean log2[peak/rest] ratio), and the coloring of the dot and the label reflect the magnitude and direction of change in the log2[peak/rest] ratio. The 66 individual metabolites with statistically significant (at FDR 5%) associations with MVPA and peak VO2 and with significant changes with exercise are labeled. Abbreviations: SED, sedentary time; MVPA, moderate-vigorous physical activity.
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