Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Nov;26(11):3576-3588.
doi: 10.1007/s10461-022-03694-6. Epub 2022 May 10.

A Comparative Analysis of Different HIV Viral Load Suppression Definitions Among Clients Receiving Care in the Miami-Dade Ryan White HIV/AIDS Program

Semiu O Gbadamosi  1 , Mary Jo Trepka  1   2 , Rahel Dawit  1 , Zoran Bursac  3 , Andrea Raymond  4 , Robert A Ladner  5 , Diana M Sheehan  6   7   8
Affiliations

A Comparative Analysis of Different HIV Viral Load Suppression Definitions Among Clients Receiving Care in the Miami-Dade Ryan White HIV/AIDS Program

Semiu O Gbadamosi et al. AIDS Behav. 2022 Nov.

Abstract

The study's objective was to examine variations in viral load (VL) suppression definitions among clients in the Ryan White Program (RWP). Data from clients enrolled in the RWP during 2017 were examined to calculate the proportion of virally suppressed clients using three definitions: recent viral suppression, defined as having a suppressed VL (< 200 copies/mL) in the last test in 2017; maintained viral suppression, having a suppressed VL for both the first and last tests in 2017; and sustained viral suppression, having all tests in 2017 showing suppression. Relative differences across all three definitions were computed. Recent viral suppression measures were higher than maintained and sustained viral suppression measures by 7.0% and 10.1%, respectively. Significant relative differences in definitions by demographic, socioeconomic and clinical status were observed. It may be beneficial for care planning to report not only estimates of recent viral suppression but maintained and sustained viral suppression as well.

Keywords: HIV; Ryan White Program; Sustained; Viral load; Viral suppression.

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest /Competing interests

Financial interests: The authors declare they have no financial interests.

Figures

Figure 1.
Figure 1.
Flowchart for inclusion of study population
Figure 2.
Figure 2.. Gwet’s agreement coefficient type 1 statistics based on definitions of measures of viral suppression
Abbreviations: AC1: Gwet’s agreement coefficient type 1; CI: confidence interval; NHB: Non-Hispanic Black; NHW: Non-Hispanic White Total sample, n= 6503; Non-Hispanic Black, n=1583; Hispanic, n=3777; Haitian, n=711; Non-Hispanic White/Other, n=432
See this image and copyright information in PMC

References

    1. Cohen MS, Chen YQ, McCauley M, Gamble T, Hosseinipour MC, Kumarasamy N, et al. Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med. 2011;365:493–505. - PMC - PubMed
    1. Quinn TC, Wawer MJ, Sewankambo N, Serwadda D, Li C, Wabwire-Mangen F, et al. Viral load and heterosexual transmission of human immunodeficiency virus type 1. N Engl J Med. 2000;342:921–9. - PubMed
    1. Mugavero MJ, Napravnik S, Cole SR, Eron JJ, Lau B, Crane HM, et al. Viremia copy-years predicts mortality among treatment-naive HIV-infected patients initiating antiretroviral therapy. Clin Infect Dis. 2011;53:927–35. - PMC - PubMed
    1. Murray JS, Elashoff MR, Iacono-Connors LC, Cvetkovich TA, Struble KA. The use of plasma HIV RNA as a study endpoint in efficacy trials of antiretroviral drugs. AIDS. 1999;13:797–804. - PubMed
    1. Marschner IC, Collier AC, Coombs RW, D’Aquila RT, DeGruttola V, Fischl MA, et al. Use of changes in plasma levels of human immunodeficiency virus type 1 RNA to assess the clinical benefit of antiretroviral therapy. J Infect Dis. 1998;177:40–7. - PubMed