Review

Glycosylphosphatidylinositol Anchors

Sneha Sudha Komath, Morihisa Fujita, Gerald W. Hart, Michael A.J. Ferguson, Taroh Kinoshita

, editors.

In: Essentials of Glycobiology [Internet]. 4th edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2022. Chapter 12.

Affiliations

Book Affiliations

¹ Distinguished Professor of Medicine and of Cellular & Molecular Medicine, Co-Director, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, USA
² Professor of Surgery, Beth Israel Deaconess Medical Center, Director, National Center for Functional Glycomics, Harvard Medical School, Boston, Massachusetts, USA
³ Distinguished Professor of Cellular & Molecular Medicine, Co-Director, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, USA
⁴ Horace W. Goldsmith Foundation Chair, Professor of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, USA
⁵ Sr. Eminent Scholar in Drug Discovery, Georgia Research Alliance William Henry Terry Professor of Biochemistry & Molecular Biology, Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA
⁶ Professor of Mycology, ETH Zürich, Institute of Microbiology, Department of Biology, Zürich, Switzerland
⁷ Distinguished Research Professor, Georgia Athletics Association Professor in Complex Carbohydrate Research, Professor of Biochemistry and Molecular Biology, Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA
⁸ Endowed Chair and Professor, Yabumoto Department of Intractable Disease Research, Research Institute for Microbial Diseases, Immunology Frontier Research Center, Osaka University, Osaka, Japan
⁹ Distinguished Professor of Molecular Sciences, Macquarie University, Sydney, Australia and Principal Research Leader, Institute for Glycomics, Griffith University, Gold Coast, Australia
¹⁰ Professor and Eminent Scholar Emeritus, Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA
¹¹ Professor, Departments of Pharmacology and Neuroscience, Johns Hopkins University, Baltimore, Maryland, USA
¹² Director of Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany, Professor, Freie Universität, Berlin, Germany

PMID: 35536964
Bookshelf ID: NBK579963
DOI: 10.1101/glycobiology.4e.12

Free Books & Documents

Review

Glycosylphosphatidylinositol Anchors

Sneha Sudha Komath et al.

Free Books & Documents

In: Essentials of Glycobiology [Internet]. 4th edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2022. Chapter 12.

Authors

Sneha Sudha Komath, Morihisa Fujita, Gerald W. Hart, Michael A.J. Ferguson, Taroh Kinoshita

Book Editors

Book Affiliations

¹ Distinguished Professor of Medicine and of Cellular & Molecular Medicine, Co-Director, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, USA
² Professor of Surgery, Beth Israel Deaconess Medical Center, Director, National Center for Functional Glycomics, Harvard Medical School, Boston, Massachusetts, USA
³ Distinguished Professor of Cellular & Molecular Medicine, Co-Director, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, USA
⁴ Horace W. Goldsmith Foundation Chair, Professor of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, USA
⁵ Sr. Eminent Scholar in Drug Discovery, Georgia Research Alliance William Henry Terry Professor of Biochemistry & Molecular Biology, Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA
⁶ Professor of Mycology, ETH Zürich, Institute of Microbiology, Department of Biology, Zürich, Switzerland
⁷ Distinguished Research Professor, Georgia Athletics Association Professor in Complex Carbohydrate Research, Professor of Biochemistry and Molecular Biology, Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA
⁸ Endowed Chair and Professor, Yabumoto Department of Intractable Disease Research, Research Institute for Microbial Diseases, Immunology Frontier Research Center, Osaka University, Osaka, Japan
⁹ Distinguished Professor of Molecular Sciences, Macquarie University, Sydney, Australia and Principal Research Leader, Institute for Glycomics, Griffith University, Gold Coast, Australia
¹⁰ Professor and Eminent Scholar Emeritus, Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA
¹¹ Professor, Departments of Pharmacology and Neuroscience, Johns Hopkins University, Baltimore, Maryland, USA
¹² Director of Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany, Professor, Freie Universität, Berlin, Germany

PMID: 35536964
Bookshelf ID: NBK579963
DOI: 10.1101/glycobiology.4e.12

Excerpt

Plasma membrane proteins are either peripheral proteins or integral membrane proteins. The latter include proteins that span the lipid bilayer once or several times, and a second class that are covalently attached to lipids. Proteins attached to glycosylphosphatidylinositol (GPI) via their carboxyl termini are generally found in the outer leaflet of the lipid bilayer facing the extracellular environment. The GPI membrane anchor may be conveniently thought of as an alternative to the single transmembrane domain of type-I integral membrane proteins. This chapter reviews the discovery, distribution, structure, biosynthesis, properties, and suggested functions of GPI anchors and related molecules, as well as their roles in diseases.

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References

1. Ferguson MA, Williams AF. 1988. Cell-surface anchoring of proteins via glycosyl-phosphatidylinositol structures. Annu Rev Biochem 57: 285–320. doi:10.1146/annurev.bi.57.070188.001441 - DOI - PubMed
1. Ferguson MA, Homans SW, Dwek RA, Rademacher TW. 1988. Glycosyl-phosphatidylinositol moiety that anchors Trypanosoma brucei variant surface glycoprotein to the membrane. Science 239: 753–759. doi:10.1126/science.3340856 - DOI - PubMed
1. Guha-Niyogi A, Sullivan DR, Turco SJ. 2001. Glycoconjugate structures of parasitic protozoa. Glycobiology 11: p45R–p59R. doi:10.1093/glycob/11.4.45r - DOI - PubMed
1. de Macedo CS, Shams-Eldin H, Smith TK, Schwarz RT, Azzouz N. 2003. Inhibitors of glycosylphosphatidylinositol anchor biosynthesis. Biochimie 85: 465–472. doi:10.1016/s0300-9084(03)00065-8 - DOI - PubMed
1. Maeda Y, Ashida H, Kinoshita T. 2006. CHO glycosylation mutants: GPI anchor. Methods Enzymol 416: 182–205. doi:10.1016/s0076-6879(06)16012-7 - DOI - PubMed

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Glycosylphosphatidylinositol Anchors

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Glycosylphosphatidylinositol Anchors

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