Review

N-Glycans

Pamela Stanley, Kelley W. Moremen, Nathan E. Lewis, Naoyuki Taniguchi, Markus Aebi

, editors.

In: Essentials of Glycobiology [Internet]. 4th edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2022. Chapter 9.

Affiliations

Book Affiliations

¹ Distinguished Professor of Medicine and of Cellular & Molecular Medicine, Co-Director, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, USA
² Professor of Surgery, Beth Israel Deaconess Medical Center, Director, National Center for Functional Glycomics, Harvard Medical School, Boston, Massachusetts, USA
³ Distinguished Professor of Cellular & Molecular Medicine, Co-Director, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, USA
⁴ Horace W. Goldsmith Foundation Chair, Professor of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, USA
⁵ Sr. Eminent Scholar in Drug Discovery, Georgia Research Alliance William Henry Terry Professor of Biochemistry & Molecular Biology, Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA
⁶ Professor of Mycology, ETH Zürich, Institute of Microbiology, Department of Biology, Zürich, Switzerland
⁷ Distinguished Research Professor, Georgia Athletics Association Professor in Complex Carbohydrate Research, Professor of Biochemistry and Molecular Biology, Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA
⁸ Endowed Chair and Professor, Yabumoto Department of Intractable Disease Research, Research Institute for Microbial Diseases, Immunology Frontier Research Center, Osaka University, Osaka, Japan
⁹ Distinguished Professor of Molecular Sciences, Macquarie University, Sydney, Australia and Principal Research Leader, Institute for Glycomics, Griffith University, Gold Coast, Australia
¹⁰ Professor and Eminent Scholar Emeritus, Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA
¹¹ Professor, Departments of Pharmacology and Neuroscience, Johns Hopkins University, Baltimore, Maryland, USA
¹² Director of Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany, Professor, Freie Universität, Berlin, Germany

PMID: 35536965
Bookshelf ID: NBK579964
DOI: 10.1101/glycobiology.4e.9

Free Books & Documents

Review

N-Glycans

Pamela Stanley et al.

Free Books & Documents

In: Essentials of Glycobiology [Internet]. 4th edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2022. Chapter 9.

Authors

Pamela Stanley, Kelley W. Moremen, Nathan E. Lewis, Naoyuki Taniguchi, Markus Aebi

Book Editors

Book Affiliations

¹ Distinguished Professor of Medicine and of Cellular & Molecular Medicine, Co-Director, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, USA
² Professor of Surgery, Beth Israel Deaconess Medical Center, Director, National Center for Functional Glycomics, Harvard Medical School, Boston, Massachusetts, USA
³ Distinguished Professor of Cellular & Molecular Medicine, Co-Director, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, USA
⁴ Horace W. Goldsmith Foundation Chair, Professor of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, USA
⁵ Sr. Eminent Scholar in Drug Discovery, Georgia Research Alliance William Henry Terry Professor of Biochemistry & Molecular Biology, Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA
⁶ Professor of Mycology, ETH Zürich, Institute of Microbiology, Department of Biology, Zürich, Switzerland
⁷ Distinguished Research Professor, Georgia Athletics Association Professor in Complex Carbohydrate Research, Professor of Biochemistry and Molecular Biology, Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA
⁸ Endowed Chair and Professor, Yabumoto Department of Intractable Disease Research, Research Institute for Microbial Diseases, Immunology Frontier Research Center, Osaka University, Osaka, Japan
⁹ Distinguished Professor of Molecular Sciences, Macquarie University, Sydney, Australia and Principal Research Leader, Institute for Glycomics, Griffith University, Gold Coast, Australia
¹⁰ Professor and Eminent Scholar Emeritus, Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA
¹¹ Professor, Departments of Pharmacology and Neuroscience, Johns Hopkins University, Baltimore, Maryland, USA
¹² Director of Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany, Professor, Freie Universität, Berlin, Germany

PMID: 35536965
Bookshelf ID: NBK579964
DOI: 10.1101/glycobiology.4e.9

Excerpt

N-Glycans are covalently attached to protein at asparagine (Asn) residues by an N-glycosidic bond. Although diverse sugars are attached to Asn in prokaryotes (Chapters 21 and 22), all eukaryotic N-glycans begin with GlcNAcβ1–Asn and are the focus of this chapter. The biosynthesis of N-glycans is most complex in mammals and is described here in detail. Terminal sugars that largely determine the diversity of N-glycans are described in Chapter 14. Glycosylation-mediated quality control of protein folding by N-glycans is presented in Chapter 39, and the mannose 6-phosphate recognition determinant on N-glycans, necessary for targeting lysosomal hydrolases to lysosomes, is described in Chapter 33. Human congenital disorders of glycosylation arising from defects in N-glycan synthesis are discussed in Chapter 45.

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References

1. Waechter CJ, Lennarz WJ. 1976. The role of polyprenol-linked sugars in glycoprotein synthesis. Annu Rev Biochem 45: 95–112. doi:10.1146/annurev.bi.45.070176.000523 - DOI - PubMed
1. Snider MD, Sultzman LA, Robbins PW. 1980. Transmembrane location of oligosaccharide-lipid synthesis in microsomal vesicles. Cell 21: 385–392. doi:10.1016/0092-8674(80)90475-4 - DOI - PubMed
1. Kornfeld R, Kornfeld S. 1985. Assembly of asparagine-linked oligosaccharides. Annu Rev Biochem 54: 631–664. doi:10.1146/annurev.bi.54.070185.003215 - DOI - PubMed
1. Herscovics A. 1999. Importance of glycosidases in mammalian glycoprotein biosynthesis. Biochim Biophys Acta 1473: 96–107. doi:10.1016/s0304-4165(99)00171-3 - DOI - PubMed
1. Berninsone PM, Hirschberg CB. 2000. Nucleotide sugar transporters of the Golgi apparatus. Curr Opin Struct Biol 10: 542–547. doi:10.1016/s0959-440x(00)00128-7 - DOI - PubMed

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N-Glycans

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N-Glycans

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