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Comment
. 2022 May 9;40(5):450-451.
doi: 10.1016/j.ccell.2022.04.010. Epub 2022 May 9.

IL-6 blockade in cancer patients treated with immune checkpoint blockade: A win-win strategy

Julie Delyon  1 , Celeste Lebbe  2
Affiliations
Free article
Comment

IL-6 blockade in cancer patients treated with immune checkpoint blockade: A win-win strategy

Julie Delyon et al. Cancer Cell. .
Free article

Abstract

Increasing the efficacy of immune checkpoint blockade therapy while mitigating toxicity is one of the major challenges in oncology research. In this issue of Cancer Cell, Hailemichael et al. provide a strong rationale for the combination of IL-6 blockade and dual inhibition of CTLA-4 and PD-1 to overcome this issue.

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Conflict of interest statement

Declaration of interests C.L. reports research funding (Roche, BMS), consulting fees (BMS, MSD, Novartis, Amgen, Roche, Merck Serono, Sanofi, Pierre Fabre), honoraria (Roche, BMS, Novartis, Amgen, MSD, Pierre Fabre, Pfizer, Incyte), speaker’s bureau membership (Roche, BMS, Novartis, Amgen, MSD), support for attending meetings (BMS, MSD, Novartis, Sanofi, Pierre Fabre), and other interests (Avantis Medical Systems). J.D. reports honoraria (BMS) and research funding (Amgen, MSD).

Comment on

  • Interleukin-6 blockade abrogates immunotherapy toxicity and promotes tumor immunity.
    Hailemichael Y, Johnson DH, Abdel-Wahab N, Foo WC, Bentebibel SE, Daher M, Haymaker C, Wani K, Saberian C, Ogata D, Kim ST, Nurieva R, Lazar AJ, Abu-Sbeih H, Fa'ak F, Mathew A, Wang Y, Falohun A, Trinh V, Zobniw C, Spillson C, Burks JK, Awiwi M, Elsayes K, Soto LS, Melendez BD, Davies MA, Wargo J, Curry J, Yee C, Lizee G, Singh S, Sharma P, Allison JP, Hwu P, Ekmekcioglu S, Diab A. Hailemichael Y, et al. Cancer Cell. 2022 May 9;40(5):509-523.e6. doi: 10.1016/j.ccell.2022.04.004. Epub 2022 May 9. Cancer Cell. 2022. PMID: 35537412 Free PMC article.

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